Sociodemographic characteristics, clinical factors, and genetic polymorphisms associated with Alzheimer's disease

Authors

  • Maria Aparecida Camargos Bicalho,

    Corresponding author
    1. Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    2. INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Brazil
    • Fundação Hospitalar do Estado de Minas Gerais, Belo Horizonte, Brazil
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  • Fausto Aloísio Pimenta,

    1. Department of Internal Medicine, Universidade Federal de Ouro, Ouro Preto, Brazil
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  • Luciana Bastos-Rodrigues,

    1. INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Brazil
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  • Érika de Oliveira Hansen,

    1. INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Brazil
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  • Samara Canguçu Neves,

    1. INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Brazil
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  • Marina Melo,

    1. INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Brazil
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  • Daniela Valadão Rosa,

    1. INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Brazil
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  • Renan Pedra de Souza,

    1. INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Brazil
    2. Department of General Biology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
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  • Débora Marques de Miranda,

    1. INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Brazil
    2. Department of Pediatrics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
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  • Edgar Nunes de Moraes,

    1. Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    2. INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Brazil
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  • Marco Aurélio Romano-Silva,

    1. INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Brazil
    2. Department of Mental Health, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
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  • Luiz De Marco

    1. INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Brazil
    2. Department of Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
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Correspondence to: M. A. C. Bicalho, E-mail macbicalho@gmail.com

Abstract

Objective

Alzheimer's disease (AD) has a multifactorial etiology involving an interaction of genetic and environmental factors. The Apolipoprotein E ε4 (ApoE ε4) is the single most important genetic risk factor for sporadic AD. Our aim was to study the association between sociodemographic, clinical data and gene polymorphisms in patients with sporadic AD in a heterogeneous genomic Brazilian population with low educational levels.

Methods

We selected 169 sporadic AD patients and 97 controls older than 65 years and compared co-variables between them: age, years of education, vascular risk factors, genomic ancestry, and functional polymorphisms of ApoE, BDNF, COMT, and 5-HTTLPR. We also determined the genomic ancestry of all individuals.

Results

The average years of education was significantly smaller in the patient's group (p = 0.003), and they had a history of depression when compared with controls (p < 0.001). The carriers of ApoE ε4 have an earlier onset of the disease (76.9 years) (p = 0.001) than ApoE ε3 (79.5 years) (p = 0.024). Patients with Met allele of Val66Met have a tendency to later onset of disease (p = 0.056). There were no differences in the genomic ancestry between groups.

Conclusion

Low level of education and history of depression were associated with AD. Public policies and intensive observation of old-age patients with lifetime history of depression, especially APOE ε4 carriers, could improve the well-being of our population. Copyright © 2012 John Wiley & Sons, Ltd.

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