See the acknowledgments for the list of the REAL.FR study group members
Weight changes in Alzheimer's disease patients with increased aberrant motor behavior
Article first published online: 4 DEC 2012
Copyright © 2012 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 28, Issue 10, pages 998–1004, October 2013
How to Cite
Secher, M., Andrieu, S., Gillette-Guyonnet, S., Soto, M., Rolland, Y., Cantet, C., Vellas, B., Ritz, P. and The REAL.fr Group (2013), Weight changes in Alzheimer's disease patients with increased aberrant motor behavior. Int. J. Geriat. Psychiatry, 28: 998–1004. doi: 10.1002/gps.3914
- Issue published online: 4 SEP 2013
- Article first published online: 4 DEC 2012
- Manuscript Accepted: 30 OCT 2012
- Manuscript Received: 28 NOV 2011
- Clinical Research Hospital Program from the French Ministry of Health. Grant Number: PHRC No. 98-47N and PHRC No. 0101001
- Alzheimer's disease;
- aberrant motor behavior;
- body weight changes
Weight loss and behavioral disturbances are frequent over the course of Alzheimer's disease (AD) and are risk factors for poor outcome. We investigated the impact of aberrant motor behavior (AMB) on weight changes in older adults with AD. The hypothesis that patients with AMB are more likely to lose weight than patients without AMB was assessed.
A prospective study of 686 patients with moderate AD from the REAL.FR cohort was assessed. The AMB at baseline was defined by the item 10 from the Neuropsychiatric Inventory scale (NPI-10). Patients were classified as “no or light AMB” (NPI-10 < 4), and “significant AMB” (NPI-10 ≥ 4). Weight changes were determined over the 4-year follow-up.
The mean weight change over the 4 years was +2.2 ± 0.9 kg in patients with “significant AMB,” whereas weight remained stable in patients with “no or light AMB” (p = 0.02).
Older adults with moderate AD and “significant AMB” do gain weight. Copyright © 2012 John Wiley & Sons, Ltd.