White matter fractional anisotropy is inversely related to anxious symptoms in older adults with atherosclerosis
Article first published online: 24 JAN 2013
Copyright © 2013 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 28, Issue 10, pages 1069–1076, October 2013
How to Cite
Bijanki, K. R., Stillman, A. N., Arndt, S., Magnotta, V. A., Fiedorowicz, J. G., Haynes, W. G., Matsui, J. T., Johnson, H. J. and Moser, D. J. (2013), White matter fractional anisotropy is inversely related to anxious symptoms in older adults with atherosclerosis. Int. J. Geriat. Psychiatry, 28: 1069–1076. doi: 10.1002/gps.3930
- Issue published online: 4 SEP 2013
- Article first published online: 24 JAN 2013
- Manuscript Accepted: 20 DEC 2012
- Manuscript Received: 30 AUG 2012
- National Institutes on Aging. Grant Number: 1 K23 AG020649-01A1, RO1AG030417-01A2
- National Center for Research Resources. Grant Number: UL1RR024979
- diffusion tensor imaging;
- longitudinal fasciculus
Clinical anxiety disorders are associated with white matter hyperintensities and diffusion abnormalities measured using diffusion tensor imaging. However, it is not known if this association extends into individuals with mild anxious symptoms without formal diagnosis, in those who are older, or in those who have atherosclerosis. The current study explores whether white matter integrity and/or organization significantly associates with anxious symptoms in older adults with and without atherosclerosis.
We recruited older adults (ages 55–90 years); 35 with clinically diagnosed atherosclerotic vascular disease (AVD) and 22 without AVD. Anxious symptoms were measured using the validated Symptom Checklist-90-Revised. Fractional anisotropy (FA), a proxy for white matter organization and health, was measured in the white matter globally, by lobe, and in several smaller regions of interest suggested by the literature. Partial correlations between anxious symptoms and FA were calculated, controlling for significant covariates.
Participants with and without AVD did not differ in severity of anxious symptom endorsement. There was a unique inverse relationship between white matter health and anxious symptoms in the AVD participants, but not in healthy comparisons. Significant relationships were observed in the superior longitudinal fasciculus (r = −0.476, df = 32, p = 0.004), as well as the cingulum bundle, the frontal lobes, and the parietal lobes.
Anxiety symptoms uniquely correlated with low FA in older adults with atherosclerosis. These findings may have implications for future research on the topic of anxiety in aging and vascular disease and warrant replication. Copyright © 2013 John Wiley & Sons, Ltd.