This article was published online on 14 May 2013. Errors in the author names were subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected [12 August 2013]
Increased frequency of cluster of differentiation 14 (CD14+) monocytes expressing interleukin 1 beta (IL-1β) in Alzheimer's disease patients and intermediate levels in late-onset depression patients†
Article first published online: 14 MAY 2013
Copyright © 2013 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 29, Issue 2, pages 137–143, February 2014
How to Cite
Torres, K. C., Lima, G. S., Fiamoncini, C. M., Rezende, V. B., Pereira, P. A., Bicalho, M. A., Moraes, E. N. and Romano-Silva, M. A. (2014), Increased frequency of cluster of differentiation 14 (CD14+) monocytes expressing interleukin 1 beta (IL-1β) in Alzheimer's disease patients and intermediate levels in late-onset depression patients. Int. J. Geriat. Psychiatry, 29: 137–143. doi: 10.1002/gps.3973
- Issue published online: 10 JAN 2014
- Article first published online: 14 MAY 2013
- Manuscript Accepted: 18 MAR 2013
- Manuscript Received: 27 NOV 2012
- INCT-MM. Grant Number: CBB-APQ-00075-09 / CNPq 573646/2008-2
- Alzheimer disease;
- late -onset depression
Depression might be a prodromal stage of dementia. Many factors contribute to the etiology of depression and dementia, being inflammation one of those. The present work measured and analyzed immune molecules involved in the innate immunity on cluster of differentiation 14 (CD14+) monocytes trying to investigate any relationship among late-onset depression (LOD) and Alzheimer's disease (AD).
Immune molecules were evaluated in monocytes of AD, LOD patients, and controls using flow cytometry.
Interestingly, interleukin 1 beta (IL-1β) expressing CD14+ monocytes were increased in AD patients compared with controls. LOD presented intermediate frequency of CD14+ monocytes expressing IL-1β between controls and AD patients.
Results suggest that an increased frequency of CD14+ monocytes expressing IL-1β level could be a stage marker related to the pathophysiology of dementia process between normal aging and AD. Copyright © 2013 John Wiley & Sons, Ltd.