Increased frequency of cluster of differentiation 14 (CD14+) monocytes expressing interleukin 1 beta (IL-1β) in Alzheimer's disease patients and intermediate levels in late-onset depression patients

Authors


  • This article was published online on 14 May 2013. Errors in the author names were subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected [12 August 2013]

Abstract

Objective

Depression might be a prodromal stage of dementia. Many factors contribute to the etiology of depression and dementia, being inflammation one of those. The present work measured and analyzed immune molecules involved in the innate immunity on cluster of differentiation 14 (CD14+) monocytes trying to investigate any relationship among late-onset depression (LOD) and Alzheimer's disease (AD).

Methods

Immune molecules were evaluated in monocytes of AD, LOD patients, and controls using flow cytometry.

Results

Interestingly, interleukin 1 beta (IL-1β) expressing CD14+ monocytes were increased in AD patients compared with controls. LOD presented intermediate frequency of CD14+ monocytes expressing IL-1β between controls and AD patients.

Conclusion

Results suggest that an increased frequency of CD14+ monocytes expressing IL-1β level could be a stage marker related to the pathophysiology of dementia process between normal aging and AD. Copyright © 2013 John Wiley & Sons, Ltd.

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