Vascular risk factors and neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study
Article first published online: 17 MAY 2013
Copyright © 2013 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 29, Issue 2, pages 153–159, February 2014
How to Cite
Steinberg, M., Hess, K., Corcoran, C., Mielke, M. M., Norton, M., Breitner, J., Green, R., Leoutsakos, J., Welsh-Bohmer, K., Lyketsos, C. and Tschanz, J. (2014), Vascular risk factors and neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study. Int. J. Geriat. Psychiatry, 29: 153–159. doi: 10.1002/gps.3980
- Issue published online: 10 JAN 2014
- Article first published online: 17 MAY 2013
- Manuscript Accepted: 3 APR 2013
- Manuscript Received: 1 OCT 2012
- NIA. Grant Numbers: R01AG21136, R01AG11380, K24AG027841
- Alzheimer's disease;
Knowledge of potentially modifiable risk factors for neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) is important. This study longitudinally explores modifiable vascular risk factors for NPS in AD.
Participants enrolled in the Cache County Study on Memory in Aging with no dementia at baseline were subsequently assessed over three additional waves, and those with incident (new onset) dementia were invited to join the Dementia Progression Study for longitudinal follow-up. A total of 327 participants with incident AD were identified and assessed for the following vascular factors: atrial fibrillation, hypertension, diabetes mellitus, angina, coronary artery bypass surgery, myocardial infarction, cerebrovascular accident, and use of antihypertensive or diabetes medicines. A vascular index (VI) was also calculated. NPS were assessed over time using the Neuropsychiatric Inventory (NPI). Affective and Psychotic symptom clusters were assessed separately. The association between vascular factors and change in NPI total score was analyzed using linear mixed model and in symptom clusters using a random effects model.
No individual vascular risk factors or the VI significantly predicted change in any individual NPS. The use of antihypertensive medications more than four times per week was associated with higher total NPI and Affective cluster scores.
Use of antihypertensive medication was associated with higher total NPI and Affective cluster scores. The results of this study do not otherwise support vascular risk factors as modifiers of longitudinal change in NPS in AD. Copyright © 2013 John Wiley & Sons, Ltd.