Peripheral inflammatory markers in amnestic mild cognitive impairment
Article first published online: 15 JUL 2013
© 2013 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons, Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
International Journal of Geriatric Psychiatry
Volume 29, Issue 3, pages 221–226, March 2014
How to Cite
Karim, S., Hopkins, S., Purandare, N., Crowther, J., Morris, J., Tyrrell, P. and Burns, A. (2014), Peripheral inflammatory markers in amnestic mild cognitive impairment. Int. J. Geriat. Psychiatry, 29: 221–226. doi: 10.1002/gps.3988
- Issue published online: 11 FEB 2014
- Article first published online: 15 JUL 2013
- Manuscript Accepted: 2 MAY 2013
- Manuscript Received: 24 JAN 2013
- inflammatory markers;
- mild cognitive impairment
To prospectively monitor plasma inflammatory marker concentrations in peripheral blood, over 12 months, in subjects with amnestic mild cognitive impairment (MCI), and to determine the relationship between peripheral inflammatory markers and cognitive decline.
Seventy patients with amnestic MCI were recruited from two sites providing specialist memory assessment services in Manchester. The baseline assessment included physical examination, neuro-psychological testing and venous blood samples for C-reactive protein (CRP) and interleukin 6 (IL-6) concentrations. Sixty two participants were followed up after 12 months and the assessments were repeated.
Data analysis revealed a significant rise in CRP, but not IL-6 concentrations over 12 months, which was not confounded by demographic variables. The neuro-psychological test scores had no association with CRP or IL-6 concentrations at baseline or 12 months follow-up.
This study adopted the unique approach of prospectively investigating peripheral inflammatory markers in a cohort with amnestic MCI. A significant rise in CRP concentrations over 12 months, but lack of significant association with cognition, provide no evidence for a relationship between systemic inflammation and cognitive decline in amnestic MCI. © 2013 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons, Ltd.