Amnestic multiple cognitive domains impairment and periventricular white matter hyperintensities are independently predictive factors progression to dementia in mild cognitive impairment
Article first published online: 10 OCT 2013
Copyright © 2013 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 29, Issue 5, pages 526–532, May 2014
How to Cite
Lee, H. K., Lee, Y. M., Park, J. M., Lee, B. D., Moon, E. S. and Chung, Y. I. (2014), Amnestic multiple cognitive domains impairment and periventricular white matter hyperintensities are independently predictive factors progression to dementia in mild cognitive impairment. Int. J. Geriat. Psychiatry, 29: 526–532. doi: 10.1002/gps.4035
- Issue published online: 7 APR 2014
- Article first published online: 10 OCT 2013
- Manuscript Accepted: 12 SEP 2013
- Manuscript Revised: 28 AUG 2013
- Manuscript Received: 15 MAR 2013
- Biomedical Research Institute. Grant Number: 2009–27
- mild cognitive impairment;
- memory impairment;
- periventricular white matter hyperintensities
Mild cognitive impairment (MCI) usually represents a transitional phase between normal cognitive function and dementia, but not all people with MCI develop dementia because MCI is a clinically and etiologically heterogeneous grouping. The aim of this study was to determine whether clinical subtypes of MCI and severity of white matter hyperintensities (WMH) were associated with progression of MCI to dementia.
Our study cohort consisted of 840 patients aged 55 years or older who had a diagnosis of MCI at their baseline visit and had at least one follow-up contact after baseline.
The results of the multivariable Cox proportional hazards model analysis revealed that both multiple domain amnestic MCI with WMH and multiple domain amnestic MCI without WMH were a significantly more likely to progress to dementia in comparison with patients with non-amnestic MCI. Logistic regression analyses showed that PWMH (periventricular white matter hyperintensities), not the deep white matter hyperintensities, was significantly associated with incident dementia.
This study showed that mdMCI + a (−NL or -WMH) are more associated with progression to dementia. We also found that increasing severity of PWMH, not deep white matter hyperintensities, was significantly associated with incident dementia, independently of subtype of MCI. It suggests that both mdMCI + a and PWMH are good prognostic factors of progression to dementia in MCI. Copyright © 2013 John Wiley & Sons, Ltd.