Age of onset and duration of dementia in people with down syndrome: Integration of 98 reported cases in the literature

Authors

  • Dr. V. P. Prasher,

    Corresponding author
    1. Lecturer in Psychiatry, University of Birmingham, UK
    • Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Mindelsohn Way, Edgbaston, Birmingham B15 2QZ, UK
    Search for more papers by this author
  • V. H. R. Krishnan

    1. Senior Registrar in Developmental Psychiatry, University of Birmingham, UK
    Search for more papers by this author

Abstract

The published case reports of 98 people with Down Syndrome were studied with respect to the age of onset and duration of clinically diagnosed dementia. The incidence of dementia was unimodal, increasing rapidly from 40 years to a peak of 30% incidence in the fifth decade of life, followed by a further rapid decline. Females with Down syndrome had an earlier onset. Duration of dementia decreased with increasing age of onset for both males and females.

Ancillary