Scopolamine-induced cognitive impairment as a predictor of cognitive decline in healthy elderly volunteers



There are theoretical grounds for believing that scopolamine-induced cognitive deficit may be predictive of future cognitive decline. In the present study, 22 healthy elderly volunteers were reassessed 3 years after a scopolamine challenge. Although there was little overall change in mean cognitive test scores over time, in two out of 10 tests scopolamine-induced decrement was related to subsequent decline.