Scopolamine-induced cognitive impairment as a predictor of cognitive decline in healthy elderly volunteers
Article first published online: 13 OCT 2004
Copyright © 1995 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 10, Issue 12, pages 1059–1062, December 1995
How to Cite
Barker, A., Jones, R., Simpson, P. and Wesnes, K. (1995), Scopolamine-induced cognitive impairment as a predictor of cognitive decline in healthy elderly volunteers. Int. J. Geriat. Psychiatry, 10: 1059–1062. doi: 10.1002/gps.930101211
- Issue published online: 13 OCT 2004
- Article first published online: 13 OCT 2004
- Manuscript Accepted: 13 MAR 1995
- Manuscript Received: 10 NOV 1994
- Alzheimer's disease;
There are theoretical grounds for believing that scopolamine-induced cognitive deficit may be predictive of future cognitive decline. In the present study, 22 healthy elderly volunteers were reassessed 3 years after a scopolamine challenge. Although there was little overall change in mean cognitive test scores over time, in two out of 10 tests scopolamine-induced decrement was related to subsequent decline.