Glutamate and the glutamate receptor system: a target for drug action
Version of Record online: 27 AUG 2003
Copyright © 2003 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Supplement: Memantine Workshop 2001, Barcelona, Spain
Volume 18, Issue Supplement 1, pages S33–S40, September 2003
How to Cite
Bleich, S., Römer, K., Wiltfang, J. and Kornhuber, J. (2003), Glutamate and the glutamate receptor system: a target for drug action. Int. J. Geriat. Psychiatry, 18: S33–S40. doi: 10.1002/gps.933
- Issue online: 27 AUG 2003
- Version of Record online: 27 AUG 2003
- Manuscript Accepted: 19 JAN 2003
- glutamate receptors;
- glutamate antagonists;
- neuroprotective treatment
Glutamate is the most important excitatory neurotransmitter in the central nervous system. In the process, glutamate fulfills numerous physiological functions, but also plays an important role in the pathophysiology of different neurological and psychiatric diseases, especially when an imbalance in glutamatergic neurotransmission occurs. Under certain conditions, glutamate has a toxic action resulting from an activation of specific glutamate receptors, which leads to acute or chronic death of nerve cells. Such mechanisms are currently under discussion in acute neuronal death within the context of hypoxia, ischaemia and traumas, as well as in chronic neurodegenerative or neurometabolic diseases, idiopathic parkinsonian syndrome, Alzheimer's dementia and Huntington's disease. It is hoped that glutamate antagonists will lead to novel therapies for these diseases, whereby the further development of glutamate antagonists for blocking disease-specific subtypes of glutamate receptors may be of major importance in the future. Copyright © 2003 John Wiley & Sons, Ltd.