Modeling of activation data in the BrainMap™ database: Detection of outliers

Authors

  • Finn Årup Nielsen,

    Corresponding author
    1. Informatics and Mathematical Modelling, Technical University of Denmark, Lyngby, Denmark
    • Informatics and Mathematical Modelling, Building 321, Technical University of Denmark, DK-2800, Lyngby, Denmark
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  • Lars Kai Hansen

    1. Informatics and Mathematical Modelling, Technical University of Denmark, Lyngby, Denmark
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Abstract

We describe a system for meta-analytical modeling of activation foci from functional neuroimaging studies. Our main vehicle is a set of density models in Talairach space capturing the distribution of activation foci in sets of experiments labeled by lobar anatomy. One important use of such density models is identification of novelty, i.e., low probability database events. We rank the novelty of the outliers and investigate the cause for 21 of the most novel, finding several outliers that are entry and transcription errors or infrequent or non-conforming terminology. We briefly discuss the use of atlases for outlier detection. Hum. Brain Mapping 15:146–156, 2002. © 2002 Wiley-Liss, Inc.

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