This article is a US Government work and, as such, is in the public domain in the United States of America.
Developmental aspects of language processing: fMRI of verbal fluency in children and adults†
Article first published online: 11 FEB 2003
Copyright © 2003 Wiley-Liss, Inc.
Human Brain Mapping
Special Issue: Functional Brain Imaging of Language
Volume 18, Issue 3, pages 176–185, March 2003
How to Cite
Gaillard, W. D., Sachs, B. C., Whitnah, J. R., Ahmad, Z., Balsamo, L. M., Petrella, J. R., Braniecki, S. H., McKinney, C. M., Hunter, K., Xu, B. and Grandin, C. B. (2003), Developmental aspects of language processing: fMRI of verbal fluency in children and adults. Hum. Brain Mapp., 18: 176–185. doi: 10.1002/hbm.10091
- Issue published online: 11 FEB 2003
- Article first published online: 11 FEB 2003
- Manuscript Accepted: 11 OCT 2002
- Manuscript Received: 14 JUL 2002
- NINDS. Grant Number: KO8-NS1663
- NICHD. Grant Number: 1P30HD40677-01
- Clinical Epilepsy Section, NINDS, NIH
- Board of Lady Visitors, Children's National Medical Center
- verbal fluency;
We examined developmental differences, in location and extent of fMRI language activation maps, between adults and children while performing a semantic fluency task. We studied 29 adults and 16 children with echo planar imaging BOLD fMRI at 1.5 T using covert semantic verbal fluency (generation of words to categories compared to rest) using a block design. Post task testing was administered to assess performance. Individual data were analyzed with an a priori region of interest approach from t maps (t = 4) and asymmetry indices (AI). Group studies were analyzed using SPM 99 (Wellcome, UK; fixed effect, corrected P < 0.0001). We found no significant differences in location or laterality of activation between adults and children for a semantic verbal fluency task. Adults activated more pixels than children in left inferior frontal gyrus and left middle frontal gyrus, but AIs were the similar across ages (r2 < 0.09). Extent or laterality of activation was not affected by performance (r2 < 0.15). The brain areas that process semantic verbal fluency are similar in children and adults. The laterality of activation does not change appreciably with age and appears to be strongly lateralized by age 7 years. Hum. Brain Mapping 18:176–185, 2003. © 2003 Wiley-Liss, Inc. Published 2003 Wiley-Liss, Inc.