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Research Article
Asymmetry of subinsular anisotropy by in vivo diffusion tensor imaging
Article first published online: 2 SEP 2003
DOI: 10.1002/hbm.10130
Copyright © 2003 Wiley-Liss, Inc.
1097-0193/asset/cover.gif?v=1&s=0cf4fa55da70dd12083759168d6ce997f3ca20ae "Human Brain Mapping")
Additional Information
How to Cite
Cao, Y., Whalen, S., Huang, J., Berger, K. L. and DeLano, M. C. (2003), Asymmetry of subinsular anisotropy by in vivo diffusion tensor imaging. Human Brain Mapping, 20: 82–90. doi: 10.1002/hbm.10130
Publication History
- Issue published online: 2 SEP 2003
- Article first published online: 2 SEP 2003
- Manuscript Accepted: 29 JUL 2003
- Manuscript Received: 30 AUG 2002
Funded by
- NINDS. Grant Number: 1R21 NS41369-01
- American Heart Association. Grant Number: 9940132N
- Abstract
- Article
- References
- Cited By
Keywords:
- speech;
- language;
- symmetry;
- left–right
Abstract
The cortical regions specialized in speech–language exhibit a left–right asymmetry, e.g., a larger cortical size in the left auditory cortex and Wernicke's area. The possibility of developmental asymmetry in axonal fibers interconnecting speech–language cortical areas can be investigated by in vivo diffusion tensor imaging. Fifteen right-handed native English speakers showed a markedly significant asymmetry (P < 0. 0005) in the relative anisotropy of water diffusion in the subinsular white matter, greater on the left. Additionally, the first principal diffusivity was greater and the second and third principal diffusivities were smaller on the left than right side. These results suggest the subinsular axonal structures developed differently between the left and right sides. A possible association between the hemispheric specialization in language and speech and the subinsular axonal fiber development is discussed. Hum. Brain Mapp. 20:82–90, 2003. © 2003 Wiley-Liss, Inc.