Separate brain regions code for salience vs. valence during reward prediction in humans
Article first published online: 15 JUN 2006
Copyright © 2006 Wiley-Liss, Inc.
Human Brain Mapping
Volume 28, Issue 4, pages 294–302, April 2007
How to Cite
Jensen, J., Smith, A. J., Willeit, M., Crawley, A. P., Mikulis, D. J., Vitcu, I. and Kapur, S. (2007), Separate brain regions code for salience vs. valence during reward prediction in humans. Hum. Brain Mapp., 28: 294–302. doi: 10.1002/hbm.20274
- Issue published online: 12 MAR 2007
- Article first published online: 15 JUN 2006
- Manuscript Accepted: 24 FEB 2006
- Manuscript Received: 8 APR 2005
- CRC chair
- computational models;
- ventral striatum;
Predicting rewards and avoiding aversive conditions is essential for survival. Recent studies using computational models of reward prediction implicate the ventral striatum in appetitive rewards. Whether the same system mediates an organism's response to aversive conditions is unclear. We examined the question using fMRI blood oxygen level-dependent measurements while healthy volunteers were conditioned using appetitive and aversive stimuli. The temporal difference learning algorithm was used to estimate reward prediction error. Activations in the ventral striatum were robustly correlated with prediction error, regardless of the valence of the stimuli, suggesting that the ventral striatum processes salience prediction error. In contrast, the orbitofrontal cortex and anterior insula coded for the differential valence of appetitive/aversive stimuli. Given its location at the interface of limbic and motor regions, the ventral striatum may be critical in learning about motivationally salient stimuli, regardless of valence, and using that information to bias selection of actions. Inc. Hum Brain Mapp, 2007. © 2006 Wiley-Liss, Inc.