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A glimpse into your vision

Authors

  • Sara L. Gonzalez Andino,

    Corresponding author
    1. Electrical Neuroimaging Group, Neurology Department, Geneva University Hospitals,Geneva, Switzerland
    2. Neurology Department, Geneva University Hospitals, Geneva, Switzerland
    • Electrical Neuroimaging Group, Neurology Department, Geneva University Hospitals,Geneva, Switzerland
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  • Rolando Grave de Peralta,

    1. Electrical Neuroimaging Group, Neurology Department, Geneva University Hospitals,Geneva, Switzerland
    2. Neurology Department, Geneva University Hospitals, Geneva, Switzerland
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  • Asaid Khateb,

    1. Laboratory of Experimental Neuropsychology, Department of Neurology, Geneva University Hospitals, Geneva, Switzerland
    2. Neuropsychology Unit, Department of Neurology, Geneva University Hospitals, Geneva, Switzerland
    3. Human Brain Mapping Laboratory, Department of Neurology and Department of Fundamental Neurosciences, University of Geneva, Geneva, Switzerland
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  • Alan J. Pegna,

    1. Laboratory of Experimental Neuropsychology, Department of Neurology, Geneva University Hospitals, Geneva, Switzerland
    2. Neuropsychology Unit, Department of Neurology, Geneva University Hospitals, Geneva, Switzerland
    3. Human Brain Mapping Laboratory, Department of Neurology and Department of Fundamental Neurosciences, University of Geneva, Geneva, Switzerland
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  • Gregor Thut,

    1. Human Brain Mapping Laboratory, Department of Neurology and Department of Fundamental Neurosciences, University of Geneva, Geneva, Switzerland
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  • Theodor Landis

    1. Neurology Department, Geneva University Hospitals, Geneva, Switzerland
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Abstract

Invasive recordings of local field potentials (LFPs) have been used to “read the mind” of monkeys in real time. Here we investigated whether noninvasive field potentials estimated from the scalp-recorded electroencephalogram (EEG) using the ELECTRA source localization algorithm could provide real-time decoding of mental states in healthy humans. By means of pattern recognition techniques on 500-ms EEG epochs, we were able to discriminate accurately from single trials which of four categories of visual stimuli the subjects were viewing. Our results show that it is possible to reproduce the decoding accuracy previously obtained in animals with invasive recordings. A comparison between the decoding results and the subjects' behavioral performance indicates that oscillatory activity (OA), elicited in specific brain regions) codes better for the visual stimulus category presented than the subjects' actual response, i.e., is insensitive to voluntary or involuntary errors. The identification of brain regions participating in the decoding process allowed us to construct 3D-functional images of the task-related OA. These images revealed the activation of brain regions known for their involvement in the processing of this type of visual stimuli. Electrical neuroimaging therefore appears to have the potential to establish what the brain is processing while the stimuli are being seen or categorized, i.e., concurrently with sensory-perceptual processes. Hum Brain Mapp 2006. © 2006 Wiley-Liss, Inc.

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