Patterns of cerebral activation during olfactory and trigeminal stimulations

Authors

  • Sandrine Lombion,

    1. Laboratoire de Neurosciences Intégratives et Cliniques, 1 Place Leclerc, Université de Franche-Comté, 25030 Besançon Cedex, France
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  • Alexandre Comte,

    1. Laboratoire de Neurosciences Intégratives et Cliniques, 1 Place Leclerc, Université de Franche-Comté, 25030 Besançon Cedex, France
    2. Département de Neuroimagerie Fonctionnelle, Service de Radiologie-CHU de Besançon, 1 Bvd Fleming, Université de Franche-Comté, 25030 Besançon Cedex, France
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  • Laurent Tatu,

    1. Laboratoire de Neurosciences Intégratives et Cliniques, 1 Place Leclerc, Université de Franche-Comté, 25030 Besançon Cedex, France
    2. Laboratoire d'Anatomie, Service d'Exploration Neuromusculaire-CHU de Besançon, 1 Bvd Fleming, Université de Franche-Comté, 25030 Besançon Cedex, France
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  • Gérard Brand,

    1. Laboratoire de Neurosciences Intégratives et Cliniques, 1 Place Leclerc, Université de Franche-Comté, 25030 Besançon Cedex, France
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  • Thierry Moulin,

    1. Laboratoire de Neurosciences Intégratives et Cliniques, 1 Place Leclerc, Université de Franche-Comté, 25030 Besançon Cedex, France
    2. Département de Neuroimagerie Fonctionnelle, Service de Radiologie-CHU de Besançon, 1 Bvd Fleming, Université de Franche-Comté, 25030 Besançon Cedex, France
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  • Jean-Louis Millot

    Corresponding author
    1. Laboratoire de Neurosciences Intégratives et Cliniques, 1 Place Leclerc, Université de Franche-Comté, 25030 Besançon Cedex, France
    • Laboratoire de Neurosciences Intégratives et Cliniques, 1 Place Leclerc, Université de Franche-Comté, 25030 Besançon Cedex, France
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Abstract

It is well known that most odorants stimulate both the olfactory system and the trigeminal system. However, the overlap between the brain processes involved in each of these sensorial perceptions is still poorly documented. This study aims to compare fMRI brain activations while smelling two odorants of a similar perceived intensity and pleasantness: phenyl ethyl alcohol (a pure olfactory stimulus) and iso-amyl-acetate (a bimodal olfactory-trigeminal stimulus) in a homogeneous sample of 15 healthy, right-handed female subjects. The analysis deals with the contrasts of brain activation patterns between these two odorant conditions. The results showed a significant recruitment of the right insular cortex, and bilaterally in the cingulate in response to the trigeminal component. These findings are discussed in relation to the characteristics of these odorants compared with those tested in previous studies. Hum Brain Mapp, 2009. © 2008 Wiley-Liss, Inc.

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