Get access

Receptor architecture of human cingulate cortex: Evaluation of the four-region neurobiological model

Authors

  • Nicola Palomero-Gallagher,

    Corresponding author
    1. Institute of Neurosciences and Biophysics-Medicine, Research Centre Jülich, Jülich, Germany
    2. JARA, Research Centre Jülich, Jülich, Germany
    3. Cingulum Neurosciences Institute, Manlius, New York
    • Institute of Neurosciences and Biophysics-Medicine, Research Centre Jülich, 52425 Jülich, Germany
    Search for more papers by this author
  • Brent A. Vogt,

    1. Cingulum Neurosciences Institute, Manlius, New York
    2. Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York
    Search for more papers by this author
  • Axel Schleicher,

    1. C. & O. Vogt Institute of Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
    Search for more papers by this author
  • Helen S. Mayberg,

    1. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia
    2. Department of Neurology, Emory University School of Medicine, Atlanta, Georgia
    Search for more papers by this author
  • Karl Zilles

    1. Institute of Neurosciences and Biophysics-Medicine, Research Centre Jülich, Jülich, Germany
    2. JARA, Research Centre Jülich, Jülich, Germany
    3. C. & O. Vogt Institute of Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
    4. Brain Imaging Centre West, Research Centre Jülich, Jülich, Germany
    Search for more papers by this author

Abstract

The structural and functional organization of the human cingulate cortex is an ongoing focus; however, human imaging studies continue to use the century-old Brodmann concept of a two region cingulate cortex. Recently, a four-region neurobiological model was proposed based on structural, circuitry, and functional imaging observations. It encompasses the anterior cingulate, midcingulate, posterior cingulate, and retrosplenial cortices (ACC, MCC, PCC, and RSC, respectively). For the first time, this study performs multireceptor autoradiography of 15 neurotransmitter receptor ligands and multivariate statistics on human whole brain postmortem samples covering the entire cingulate cortex. We evaluated the validity of Brodmann's duality concept and of the four-region model using a hierarchical clustering analysis of receptor binding according to the degree of similarity of each area's receptor architecture. We could not find support for Brodmann's dual cingulate concept, because the anterior part of his area 24 has significantly higher AMPA, kainate, GABAB, benzodiazepine, and M3 but lower NMDA and GABAA binding site densities than the posterior part. The hierarchical clustering analysis distinguished ACC, MCC, PCC, and RSC as independent regions. The ACC has highest AMPA, kainate, α2, 5-HT1A, and D1 but lowest GABAA densities. The MCC has lowest AMPA, kainate, α2, and D1 densities. Area 25 in ACC is similar in receptor-architecture to MCC, particularly the NMDA, GABAA, GABAB, and M2 receptors. The PCC and RSC differ in the higher M1 and α1 but lower M3 densities of PCC. Thus, multireceptor autoradiography supports the four-region neurobiological model of the cingulate cortex. Hum Brain Mapp, 2009. © 2008 Wiley-Liss, Inc.

Ancillary