Potential conflict of interest: None declared.
Cortical mapping of naming errors in aphasia†
Article first published online: 17 MAR 2009
Copyright © 2009 Wiley-Liss, Inc.
Human Brain Mapping
Volume 30, Issue 8, pages 2487–2498, August 2009
How to Cite
Fridriksson, J., Baker, J. M. and Moser, D. (2009), Cortical mapping of naming errors in aphasia. Hum. Brain Mapp., 30: 2487–2498. doi: 10.1002/hbm.20683
- Issue published online: 9 JUL 2009
- Article first published online: 17 MAR 2009
- Manuscript Accepted: 22 SEP 2008
- Manuscript Received: 1 AUG 2008
- National Institute of Deafness and other Communication Disorders. Grant Number: R01 DC008355
- speech errors;
- right hemisphere;
Persons with aphasia vary greatly with regard to clinical profile; yet, they all share one common feature—anomia—an impairment in naming common objects. Previous research has demonstrated that particular naming errors are associated with specific left hemisphere lesions. However, we know very little about the cortical activity in the preserved brain areas that is associated with aphasic speech errors. Utilizing functional magnetic resonance imaging (fMRI), we show for the first time that specific speech errors are associated with common cortical activity in different types and severities of aphasia. Specifically, productions of phonemic errors recruited the left posterior perilesional occipital and temporal lobe areas. A similar pattern of activity was associated with semantic errors, albeit in the right hemisphere. This study does not discount variability in cortical activity following left hemisphere stroke; rather, it highlights commonalities in brain modulation in a population of patients with a common diagnosis but vastly different clinical profiles. Hum Brain Mapp 2009. © 2009 Wiley-Liss, Inc.