Abnormal white matter integrity in young children with autism

Authors

  • Maya Weinstein,

    1. Functional Brain Center—The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    2. Department of Psychology, The Hebrew University, Jerusalem, Israel
    Search for more papers by this author
  • Liat Ben-Sira,

    1. Functional Brain Center—The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Search for more papers by this author
  • Yonata Levy,

    1. Department of Psychology, The Hebrew University, Jerusalem, Israel
    Search for more papers by this author
  • Ditza A. Zachor,

    1. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    2. Department of Pediatric, Autism Center, Assaf Harofe Medical Center, Zrifin Beer-Yaakov, Israel
    Search for more papers by this author
  • Esti Ben Itzhak,

    1. Department of Pediatric, Autism Center, Assaf Harofe Medical Center, Zrifin Beer-Yaakov, Israel
    2. Department of Communication Disorder, Ariel University Center, Ariel, Israel
    Search for more papers by this author
  • Moran Artzi,

    1. Functional Brain Center—The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Search for more papers by this author
  • Ricardo Tarrasch,

    1. Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Search for more papers by this author
  • Perla M. Eksteine,

    1. Department of Anesthesia and Critical Care, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Search for more papers by this author
  • Talma Hendler,

    1. Functional Brain Center—The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    3. Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Search for more papers by this author
  • Dafna Ben Bashat

    Corresponding author
    1. Functional Brain Center—The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    • Functional Brain Center, The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Search for more papers by this author

Abstract

This study investigated white matter integrity in young children with autism using diffusion tensor imaging (DTI). Twenty-two children with autism, mean age 3:2 years, and 32 controls, mean age 3:4 years, participated in the study. Tract-based spatial statistics (TBSS) revealed white matter abnormalities in several distinct clusters within the genu and body of the corpus callosum (CC), left superior longitudinal fasciculus (SLF) and right and left cingulum (Cg). TBSS–VOIs analysis was performed in the clusters where differences in fractional anisotropy (FA) were detected to investigate the relationship between changes in FA and diffusivity indices. In all VOIs, increase in FA was caused by a decrease in radial diffusivity (Dr), while no changes in axial diffusivity (Da) or mean diffusivity (MD) were observed. Tractography analysis was applied to further study the CC, SLF, and Cg. Witelson parcellation scheme was used for the CC. Significant increase in FA was seen in children with autism in the mid-body of the CC as well as in the left Cg. It is suggested that such abnormal white matter integrity in young children with autism may adversely affect connectivity between different brain regions and may be linked to some of the behavioral impairments apparent in autism. Hum Brain Mapp, 2011. © 2010 Wiley-Liss, Inc.

Ancillary