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Functional connectivity of cortical motor areas in the resting state in Parkinson's disease

Authors

  • Tao Wu,

    Corresponding author
    1. Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Beijing, China
    • Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
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  • Xiangyu Long,

    1. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
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  • Liang Wang,

    1. Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China
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  • Mark Hallett,

    1. Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
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  • Yufeng Zang,

    1. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
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  • Kuncheng Li,

    1. Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China
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  • Piu Chan

    1. Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Beijing, China
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Abstract

Parkinson's disease (PD) patients have difficulty in initiating movements. Previous studies have suggested that the abnormal brain activity may happen not only during performance of self-initiated movements but also in the before movement (baseline or resting) state. In the current study, we investigated the functional connectivity of brain networks in the resting state in PD. We chose the rostral supplementary motor area (pre-SMA) and bilateral primary motor cortex (M1) as “seed” regions, because the pre-SMA is important in motor preparation, whereas the M1 is critical in motor execution. FMRIs were acquired in 18 patients and 18 matched controls. We found that in the resting state, the pattern of connectivity with both the pre-SMA or the M1 was changed in PD. Connectivity with the pre-SMA in patients with PD compared to normal subjects was increased connectivity to the right M1 and decreased to the left putamen, right insula, right premotor cortex, and left inferior parietal lobule. We only found stronger connectivity in the M1 with its own local region in patients with PD compared to controls. Our findings demonstrate that the interactions of brain networks are abnormal in PD in the resting state. There are more connectivity changes of networks related to motor preparation and initiation than to networks of motor execution in PD. We postulate that these disrupted connections indicate a lack of readiness for movement and may be partly responsible for difficulty in initiating movements in PD. Hum Brain Mapp, 2010. © 2010 Wiley-Liss, Inc.

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