Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: Implications for photophobia
Article first published online: 17 FEB 2011
Copyright © 2011 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 33, Issue 1, pages 75–88, January 2012
How to Cite
Maleki, N., Becerra, L., Upadhyay, J., Burstein, R. and Borsook, D. (2012), Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: Implications for photophobia. Hum. Brain Mapp., 33: 75–88. doi: 10.1002/hbm.21194
- Issue published online: 13 DEC 2011
- Article first published online: 17 FEB 2011
- Manuscript Accepted: 29 SEP 2010
- Manuscript Received: 18 AUG 2010
- NINDS. Grant Numbers: R01 NS056195, K24 NS064050
- nonimage forming pathway;
- visual pathway;
- central sensitization;
The pathway that underlies exacerbation of migraine headache by light has not been elucidated in the human brain but has recently been reported in a rodent model. We employ diffusion weighted imaging and probabilistic tractography to map connectivity of direct pathways from the optic nerve to the pulvinar implicated with whole-body allodynia during migraine. Nine healthy subjects were recruited to the study and underwent scanning on a 3T magnet. We were able to define well-known image-forming (optic nerve -> lateral geniculate -> visual cortex) as well as a less known nonimage forming visual pathway from the optic chiasm to the pulvinar, and from the pulvinar to several associative cortical brain regions. Such pathway may allow photic signals to converge on a thalamic region we described recently to be selectively activated during migraine headache. Consistent with physiological and anatomical studies in rats, the data provide an anatomical substrate for exacerbation of migraine headache by light in the human. Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc.