Thalamic-insular dysconnectivity in schizophrenia: Evidence from structural equation modeling

Authors

  • Corrado Corradi-Dell'Acqua,

    1. Swiss Centre for Affective Sciences, University of Geneva, Geneva, Switzerland
    2. Cognitive Neuroscience Sector, Scuola Internazionale Superiore di Studi Avanzati (SISSA/ISAS), Trieste, Italy
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  • Luisa Tomelleri,

    1. Section of Psychiatry and Clinical Psychology, Department of Public Health and Community Medicine, University of Verona, Verona, Italy
    2. Inter-University Center for Behavioral Neurosciences, University of Verona, Verona, Italy
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  • Marcella Bellani,

    1. Section of Psychiatry and Clinical Psychology, Department of Public Health and Community Medicine, University of Verona, Verona, Italy
    2. Inter-University Center for Behavioral Neurosciences, University of Verona, Verona, Italy
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  • Gianluca Rambaldelli,

    1. Section of Psychiatry and Clinical Psychology, Department of Public Health and Community Medicine, University of Verona, Verona, Italy
    2. Inter-University Center for Behavioral Neurosciences, University of Verona, Verona, Italy
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  • Roberto Cerini,

    1. Service of Radiology, Policlinico GB Rossi Hospital, Verona, Italy
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  • Roberto Pozzi-Mucelli,

    1. Section of Radiology, Department of Morphological and Biomedical Sciences, University of Verona, Verona, Italy
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  • Matteo Balestrieri,

    1. Inter-University Center for Behavioral Neurosciences, Department of Experimental and Clinical Medical Sciences (DSMSC), University of Udine, Udine, Italy
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  • Michele Tansella,

    1. Section of Psychiatry and Clinical Psychology, Department of Public Health and Community Medicine, University of Verona, Verona, Italy
    2. Inter-University Center for Behavioral Neurosciences, University of Verona, Verona, Italy
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  • Paolo Brambilla

    Corresponding author
    1. Inter-University Center for Behavioral Neurosciences, Department of Experimental and Clinical Medical Sciences (DSMSC), University of Udine, Udine, Italy
    2. IRCCS “E. Medea”, Scientific Institute, Udine, Italy
    • Dipartimento di Patologia e Medicina Clinica e Sperimentale, Cattedra di Psichiatria, Policlinico Universitario, Via Colugna 50, 33100 Udine, Italy
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Abstract

Structural and functional studies have shown that schizophrenia is often associated with frontolimbic abnormalities in the prefrontal and mediotemporal regions. It is still unclear, however, if such dysfunctional interaction extends as well to relay regions such as the thalamus and the anterior insula. Here, we measured gray matter volumes of five right-hemisphere regions in 68 patients with schizophrenia and 77 matched healthy subjects. The regions were amygdala, thalamus, and entorhinal cortex (identified as anomalous by prior studies on the same population) and dorsolateral prefrontal cortex and anterior insula (isolated by voxel-based morphometry analysis). We used structural equation modeling and found altered path coefficients connecting the thalamus to the anterior insula, the amygdala to the DLPFC, and the entorhinal cortex to the DLPFC. In particular, patients exhibited a stronger thalamus-insular connection than healthy controls. Instead, controls showed positive entorhinal-DLPFC and negative amygdalar-DLPFC connections, both of which were absent in the clinical population. Our data provide evidence that schizophrenia is characterized by an impaired right-hemisphere network, in which intrahemispheric communication involving relay structures may play a major role in sustaining the pathophysiology of the disease. Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc.

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