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Motor imagery evokes increased somatosensory activity in parkinson's disease patients with tremor

Authors

  • Rick C. Helmich,

    Corresponding author
    1. Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, the Netherlands
    2. Department of Neurology and Parkinson Centre Nijmegen (ParC), Radboud University Nijmegen Medical Centre, the Netherlands
    • Radboud University Nijmegen Medical Centre, Department of Neurology (HP 935), PO Box 9101, 6500 HB Nijmegen, Netherlands
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  • Bastiaan R. Bloem,

    1. Department of Neurology and Parkinson Centre Nijmegen (ParC), Radboud University Nijmegen Medical Centre, the Netherlands
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  • Ivan Toni

    1. Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, the Netherlands
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Abstract

Parkinson's disease (PD) is surprisingly heterogeneous: some patients have a prominent resting tremor, while others never develop this symptom. Here we investigate whether the functional organization of the voluntary motor system differs between PD patients with and without resting tremor, and whether these differences relate to the cerebral circuit producing tremor. We compared 18 PD patients with marked tremor, 20 PD patients without tremor, and 19 healthy controls. Subjects performed a controlled motor imagery task during fMRI scanning. We quantified imagery-related cerebral activity by contrasting imagery of biomechanically difficult and easy movements. Tremor-related activity was identified by relating cerebral activity to fluctuations in tremor amplitude, using electromyography during scanning. PD patients with tremor had better behavioral performance than PD patients without tremor. Furthermore, tremulous PD patients showed increased imagery-related activity in somatosensory area 3a, as compared with both healthy controls and to nontremor PD patients. This effect was independent from tremor-related activity, which was localized to the motor cortex, cerebellum, and thalamic ventral intermediate nucleus (VIM). The VIM, with known projections to area 3a, was unique in showing both tremor- and imagery-related responses. We conclude that parkinsonian tremor influences motor imagery by modulating central somatosensory processing through the VIM. This mechanism may explain clinical differences between PD patients with and without tremor. Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc

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