Seeing touch and pain in a stranger modulates the cortical responses elicited by somatosensory but not auditory stimulation
Article first published online: 10 JAN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 33, Issue 12, pages 2873–2884, December 2012
How to Cite
Valentini, E., Liang, M., Aglioti, S. M. and Iannetti, G. D. (2012), Seeing touch and pain in a stranger modulates the cortical responses elicited by somatosensory but not auditory stimulation. Hum. Brain Mapp., 33: 2873–2884. doi: 10.1002/hbm.21408
- Issue published online: 7 NOV 2012
- Article first published online: 10 JAN 2012
- Manuscript Accepted: 22 JUN 2011
- Manuscript Revised: 13 JUN 2011
- Manuscript Received: 16 MAR 2011
- GDI is grateful to El.En.
- pain observation;
- source analysis
Viewing other's pain inhibits the excitability of the motor cortex and also modulates the neural activity elicited by a concomitantly delivered nociceptive somatosensory stimulus. As the neural activity elicited by a transient nociceptive stimulus largely reflects non nociceptive-specific, multimodal neural processes, here we tested, for the first time, whether the observation of other's pain preferentially affects the brain responses elicited by nociceptive stimulation, or instead similarly modulates those elicited by stimuli belonging to a different sensory modality. Using 58-channel electroencephalography (EEG), we recorded the cortical responses elicited by laser and auditory stimulation during the observation of videoclips showing either noxious or non-noxious stimulation of a stranger's hand. We found that the observation of other's pain modulated the cortical activity consisting in an event-related desynchronization in the β band (β ERD), and elicited by nociceptive laser stimuli, but not by auditory stimuli. Using three different source analysis approaches, we provide converging evidence that such modulation affected neural activity in the contralateral primary sensorimotor cortex. The magnitude of this modulation correlated well with a subjective measure of similarity between the model's hand and the onlooker's representation of the hand. Altogether, these findings demonstrate that the observation of other's pain modulates, in a somatosensory-specific fashion, the cortical responses elicited by nociceptive stimuli in the sensorimotor cortex contralateral to the stimulated hand. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.