Dynamically changing effects of corticosteroids on human hippocampal and prefrontal processing
Article first published online: 21 SEP 2011
Copyright © 2011 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 33, Issue 12, pages 2885–2897, December 2012
How to Cite
Henckens, M. J.A.G., Pu, Z., Hermans, E. J., van Wingen, G. A., Joëls, M. and Fernández, G. (2012), Dynamically changing effects of corticosteroids on human hippocampal and prefrontal processing. Hum. Brain Mapp., 33: 2885–2897. doi: 10.1002/hbm.21409
- Issue published online: 7 NOV 2012
- Article first published online: 21 SEP 2011
- Manuscript Accepted: 20 JUL 2011
- Manuscript Revised: 9 MAY 2011
- Manuscript Received: 7 FEB 2011
- Dutch Organization for Scientific Research (NWO). Grant Number: 918.66.613
- prefrontal cortex;
Stress has a powerful impact on memory. Corticosteroids, released in response to stress, are thought to mediate, at least in part, these effects by affecting neuronal plasticity in brain regions involved in memory formation, including the hippocampus and prefrontal cortex. Animal studies have delineated aspects of the underlying physiological mechanisms, revealing rapid, nongenomic effects facilitating synaptic plasticity, followed several hours later by a gene-mediated suppression of this plasticity. Here, we tested the hypothesis that corticosteroids would also rapidly upregulate and slowly downregulate brain regions critical for episodic memory formation in humans. To target rapid and slow effects of corticosteroids on neural processing associated with memory formation, we investigated 18 young, healthy men who received 20 mg hydrocortisone either 30 or 180 min before a memory encoding task in a double-blind, placebo-controlled, counter-balanced, crossover design. We used functional MRI to measure neural responses during these memory encoding sessions, which were separated by a month. Results revealed that corticosteroids' slow effects reduced both prefrontal and hippocampal responses, while no significant rapid actions of corticosteroids were observed. Thereby, this study provides initial evidence for dynamically changing corticosteroid effects on brain regions involved in memory formation in humans. Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc.