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Altered brain activation during response inhibition in children with primary nocturnal enuresis: An fMRI study

Authors

  • Du Lei,

    1. Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China
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  • Jun Ma,

    1. Department of Developmental and Behavioral Pediatrics of Shanghai Children's Medical Center, XinHua Hospital Affiliated With Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Children's Environmental Health, Shanghai 200127, China
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  • Xiaoxia Du,

    Corresponding author
    1. Department of Physics, East China Normal University, Shanghai 200062, China
    • Department of Physics, East China Normal University, 3663 North Zhong-Shan Road, 200062 Shanghai, People's Republic of China
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  • Guohua Shen,

    1. Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China
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  • Minlu Tian,

    1. School of Sports Sociology, Shanghai University of Sport, Shanghai 200438, China
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  • Gengying Li

    Corresponding author
    1. Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China
    • Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China
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Abstract

Nocturnal enuresis is a common developmental disorder in children, and primary nocturnal enuresis (PNE) is the dominant subtype. The main purpose of this study was to investigate brain functional abnormalities specifically related to motor response inhibition in children with PNE using fMRI in combination with a Go/NoGo task. Twenty-two children with PNE and 22 healthy children, group-matched for age and sex, took part in this experiment. Although no significant between-group differences in task performance accuracy were observed, PNE patients showed significantly longer response times on average. There were several brain regions with reduced activation during motor response inhibition in children with PNE: the bilateral inferior frontal gyri, right superior and middle frontal gyri, right inferior parietal lobe, bilateral cingulate gyri and insula. Our data indicate that response inhibition in children with PNE is associated with a relative lack of or delay in the maturation of prefrontal cortex circuitry that is known to suppress inappropriate responses. This result might give clues to understanding the pathophysiology of PNE. Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc.

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