Research Article

Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence†

  1. Christina Schilling1,2,*,
  2. Simone Kühn1,3,
  3. Alexander Romanowski1,
  4. Tobias Banaschewski4,
  5. Alexis Barbot5,
  6. Gareth J. Barker6,
  7. Rüdiger Brühl7,
  8. Christian Büchel8,
  9. Katrin Charlet1,
  10. Patricia J. Conrod6,
  11. Katharina Czech1,
  12. Jeff W. Dalley9,10,
  13. Herta Flor11,
  14. Ines Häke1,
  15. Bernd Ittermann7,
  16. Nikolay Ivanov1,
  17. Karl Mann12,
  18. Katharina Lüdemann1,
  19. Jean-Luc Martinot13,14,
  20. Carla Palafox1,
  21. Tomas Paus15,16,17,
  22. Jean-Baptiste Poline5,
  23. Jan Reuter1,
  24. Marcella Rietschel18,
  25. Trevor W. Robbins10,
  26. Michael N. Smolka19,20,
  27. Andreas Ströhle1,
  28. Bernadeta Walaszek7,
  29. Norbert Kathmann2,
  30. Gunter Schumann6,
  31. Andreas Heinz1,
  32. Hugh Garavan21,
  33. Jürgen Gallinat1,
  34. the IMAGEN consortium

Article first published online: 11 NOV 2011

DOI: 10.1002/hbm.21446

Issue

Human Brain Mapping

Human Brain Mapping

Volume 34, Issue 2, pages 374–383, February 2013

Additional Information

How to Cite

Schilling, C., Kühn, S., Romanowski, A., Banaschewski, T., Barbot, A., Barker, G. J., Brühl, R., Büchel, C., Charlet, K., Conrod, P. J., Czech, K., Dalley, J. W., Flor, H., Häke, I., Ittermann, B., Ivanov, N., Mann, K., Lüdemann, K., Martinot, J.-L., Palafox, C., Paus, T., Poline, J.-B., Reuter, J., Rietschel, M., Robbins, T. W., Smolka, M. N., Ströhle, A., Walaszek, B., Kathmann, N., Schumann, G., Heinz, A., Garavan, H., Gallinat, J. and the IMAGEN consortium (2013), Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence. Hum. Brain Mapp., 34: 374–383. doi: 10.1002/hbm.21446

Author Information

  1. 1

    Department of Psychiatry and Psychotherapy, Charité University Medicine Campus Mitte, Berlin, Germany

  2. 2

    Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany

  3. 3

    Department of Experimental Psychology and Ghent, Institute for Functional and Metabolic Imaging, Ghent, Belgium

  4. 4

    Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Mannheim, Germany

  5. 5

    Neurospin, Commissariat à l'Energie Atomique, Paris, France

  6. 6

    Centre for Neuroimaging Sciences, King's College London, Institute of Psychiatry, London, United Kingdom

  7. 7

    Physikalisch-Technische Bundesanstalt, Berlin, Germany

  8. 8

    Institut für Systemische Neurowissenschaften, Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany

  9. 9

    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom

  10. 10

    Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom

  11. 11

    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany

  12. 12

    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany

  13. 13

    Neuroimaging & psychiatry, Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Imaging and Psychiatry,” University Paris Sud, Orsay, France

  14. 14

    AP-HP Department of Adolescent Psychopathology and Medicine, Maison de Solenn, University Paris Descartes, Paris, France

  15. 15

    Population Neuroscience, Rotman Research Institute, University of Toronto, Toronto, Canada

  16. 16

    Cognitive Neuroscience Unit/Neuropsychology Department, Montreal Neurological Institute, McGill University, Montreal, Canada

  17. 17

    School of Psychology, University of Nottingham, Nottingham, United Kingdom

  18. 18

    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany

  19. 19

    Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany

  20. 20

    Neuroimaging Center, Systems Neuroscience, Department of Psychology, Technische Universität Dresden, Dresden, Germany

  21. 21

    Department of Psychology, Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland

*Charité Medicine Berlin, Clinic for Psychiatry and Psychotherapy, St. Hedwig Krankenhaus, Große Hamburger Str. 5-11, 10115 Berlin, Germany

  1. †

    The IMAGEN study receives research funding from the European Community's Sixth Framework Programme (LSHM-CT-2007-037286) and is supported by the UK Department of Health NIHR-Biomedical Research Centre ‘Mental Health’ and the MRC programme grant “Developmental pathways into adolescents' substance abuse.”

Publication History

  1. Issue published online: 4 JAN 2013
  2. Article first published online: 11 NOV 2011
  3. Manuscript Accepted: 27 JUL 2011
  4. Manuscript Revised: 8 JUN 2011
  5. Manuscript Received: 20 FEB 2011

Funded by

  • Studienstiftung des Deutschen Volkes
  • European Community's Sixth Framework Programme. Grant Number: LSHM-CT-2007-037286
  • UK Department of Health NIHR-Biomedical Research Centre “Mental Health”
  • The MRC programme grant “Developmental pathways into adolescents' substance abuse.”

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Keywords:

  • trait;
  • impulsiveness;
  • structural correlates;
  • frontal cortex;
  • perceptual reasoning;
  • adolsecence

Abstract

Background: Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project. Methods: Clusters of gray matter (GM) volume associated with trait impulsiveness, Cloningers' revised temperament, and character inventory impulsiveness (TCI-R-I) were identified in a whole brain analysis using optimized voxel-based morphometry in 115 healthy 14-year-olds. The clusters were tested for correlations with performance on the nonverbal tests (Block Design, BD; Matrix Reasoning, MT) of the Wechsler Scale of Intelligence for Children IV reflecting perceptual reasoning. Results: Cloningers' impulsiveness (TCI-R-I) score was significantly inversely associated with GM volume in left orbitofrontal cortex (OFC). Frontal clusters found were positively correlated with performance in perceptual reasoning tasks (Bonferroni corrected). No significant correlations between TCI-R-I and perceptual reasoning were observed. Conclusions: The neural correlate of trait impulsiveness in the OFC matches an area where brain function has previously been related to inhibitory control. Additionally, orbitofrontal GM volume was associated with scores for perceptual reasoning. The data show for the first time structural correlates of both cognitive functioning and impulsiveness in healthy adolescent subjects. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.

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