Neural events leading to and associated with detection of sounds under high processing load
Article first published online: 18 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 34, Issue 3, pages 587–597, March 2013
How to Cite
Sabri, M., Humphries, C., Binder, J. R. and Liebenthal, E. (2013), Neural events leading to and associated with detection of sounds under high processing load. Hum. Brain Mapp., 34: 587–597. doi: 10.1002/hbm.21457
- Issue published online: 5 FEB 2013
- Article first published online: 18 NOV 2011
- Manuscript Accepted: 12 AUG 2011
- Manuscript Revised: 14 JUL 2011
- Manuscript Received: 21 MAR 2011
- National Institutes of Health. Grant Numbers: F32 DC007030, R01 DC006287
- National Institutes of Health, General Clinical Research Center. Grant Number: M01-RR00058.
The neural events that lead to successful or failed detection of suprathreshold sounds are not well established. In this experiment, event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI) were recorded while participants performed two tasks: a primary difficult duration judgment task on a sequence of tones presented to one ear, and a secondary target detection task on an auditory oddball stream presented to the other ear. The paradigm was designed to elicit competition and variability in detection of auditory targets despite identical input. Successful detection of auditory targets was associated mainly with greater fMRI activity in superior parietal cortex and thalamus. In the ERPs, successful detection was linked with a larger fronto-central negativity at 200–400 ms, and a later centro-posterior positivity. Failure to detect targets was associated with greater fMRI signal in the default mode network, a significantly smaller electrical fronto-central negativity and no late positivity. These findings demonstrate that variability in auditory detection is related to modulation of activity in multimodal parietal and frontal networks active ∼ 200 ms after target onset. Results are consistent with a limited capacity and late selection view of attention. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.