• Please log in or register to access this feature.

Research Article

You have free access to this content

Aberrations in the arcuate fasciculus are associated with auditory verbal hallucinations in psychotic and in non-psychotic individuals

  1. Antoin D. de Weijer*,
  2. Sebastiaan F.W. Neggers,
  3. Kelly M.S. Diederen,
  4. René C.W. Mandl,
  5. René S. Kahn,
  6. Hilleke E. Hulshoff Pol,
  7. Iris E. Sommer

Article first published online: 23 NOV 2011

DOI: 10.1002/hbm.21463

Issue

Human Brain Mapping

Human Brain Mapping

Volume 34, Issue 3, pages 626–634, March 2013

Additional Information

How to Cite

de Weijer, A. D., Neggers, S. F.W., Diederen, K. M.S., Mandl, R. C.W., Kahn, R. S., Hulshoff Pol, H. E. and Sommer, I. E. (2013), Aberrations in the arcuate fasciculus are associated with auditory verbal hallucinations in psychotic and in non-psychotic individuals. Hum. Brain Mapp., 34: 626–634. doi: 10.1002/hbm.21463

Author Information

  1. Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands

*Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, Room B.01.1.43, 3584 CX Utrecht, the Netherlands

Publication History

  1. Issue published online: 5 FEB 2013
  2. Article first published online: 23 NOV 2011
  3. Manuscript Accepted: 15 AUG 2011
  4. Manuscript Revised: 12 AUG 2011
  5. Manuscript Received: 17 MAY 2011

Funded by

  • NWO/ZonMW (Dutch Scientific Research Organization) Clinical Fellowship 2009. Grant Number: 4000703-97-270
  • NWO/(Dutch Scientific Research Organization) Innovation Impulse (VIDI) 2009. Grant Number: 017.106.301

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (3940K)

REFERENCES

  • Andersson JL, Skare S ( 2002): A model-based method for retrospective correction of geometric distortions in diffusion-weighted EPI. Neuroimage 16: 177–199.
  • Andersson JL, Skare S, Ashburner J ( 2003): How to correct susceptibility distortions in spin-echo echo-planar images: Application to diffusion tensor imaging. Neuroimage 20: 870–888.
  • Andreasen NC, Flaum M, Arndt S ( 1992): The comprehensive assessment of symptoms and history (CASH). An instrument for assessing diagnosis and psychopathology. Arch Gen Psychiatry 49: 615–623.
  • Ashburner J, Friston KJ ( 2005): Unified segmentation. Neuroimage 26: 839–851.
  • Barkovich AJ ( 2000): Concepts of myelin and myelination in neuroradiology. AJNR Am J Neuroradiol 21: 1099–1109.
  • Basser PJ, Pierpaoli C ( 1996): Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 111: 209–219.
  • Bozzali M, Wrabetz L ( 2004): Axonal signals and oligodendrocyte differentiation. Neurochem Res 29: 979–988.
  • Chang LC, Jones DK, Pierpaoli C ( 2005): RESTORE: Robust estimation of tensors by outlier rejection. Magn Reson Med 53: 1088–1095.
    Direct Link:
  • Daalman K, Boks MP, Diederen KM, de Weijer AD, Blom JD, Kahn RS, Sommer IE ( 2011): The same or different? A phenomenological comparison of auditory verbal hallucinations in healthy and psychotic individuals. J Clin Psychiatry 72: 320–325.
  • de Weijer AD, Mandl RCW, Diederen KMJ, Neggers SFW, Kahn RS, Hulshoff Pol HE, Sommer IEC ( 2011): Microstructural alterations of the arcuate fasciculus in schizophrenia patients with frequent auditory verbal hallucinations. Schizophr Res 130: 68–77.
  • Diederen KMJ, Neggers SF, Daalman K, Blom JD, Goekoop R, Kahn RS, Sommer IE ( 2010): Deactivation of the parahippocampal gyrus preceding auditory hallucinations in schizophrenia. Am J Psychiatry 167: 427–435.
  • Diederen KMJ, Daalman K, de Weijer AD, Neggers SFW, van Gastel W, Blom JD, Kahn RS, Sommer IEC ( 2011): Auditory hallucinations elicit similar brain activation in psychotic and non-psychotic individuals. Schizophr Bull. April 28, 2011 [Epub ahead of print].
  • Feinberg I ( 1978): Efference copy and corollary discharge: Implications for thinking and its disorders. Schizophr Bull 4: 636–640.
  • Ford JM, Roach BJ, Faustman WO, Mathalon DH ( 2007): Synch before you speak: Auditory hallucinations in schizophrenia. Am J Psychiatry 164: 458–466.
  • Frith CD ( 1992): The Cognitive Neuropsychology of Schizophrenia. Hove: Erlbaum.
  • Hao Y, Yan Q, Liu H, Xu L, Xue Z, Song X, Kaneko Y, Jiang T, Liu Z, Shan B ( 2009): Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex. Schizophr Res 114: 128–135.
  • Hazlett EA, Goldstein KE, Tajima-Pozo K, Speidel ER, Zelmanova Y, Entis JJ, Silverman JM, New AS, Koenigsberg HW, Haznedar MM, Byne W, Siever LJ ( 2011): Cingulate and temporal lobe fractional anisotropy in schizotypal personality disorder. Neuroimage 55:900–908.
  • Heinks-Maldonado TH, Mathalon DH, Houde JF, Gray M, Faustman WO, Ford JM ( 2007): Relationship of imprecise corollary discharge in schizophrenia to auditory hallucinations. Arch Gen Psychiatry 64: 286–296.
  • Henkelman RM, Stanisz GJ, Graham SJ ( 2001): Magnetization transfer in MRI: A review. NMR Biomed 14: 57–64.
    Direct Link:
  • Ho BC, Andreasen NC, Ziebell S, Pierson R, Magnotta V ( 2011): Long-term antipsychotic treatment and brain volumes: A longitudinal study of first-episode schizophrenia. Arch Gen Psychiatry 68: 128–137.
  • Hoptman MJ, Nierenberg J, Bertisch HC, Catalano D, Ardekani BA, Branch CA, Delisi LE ( 2008): A DTI study of white matter microstructure in individuals at high genetic risk for schizophrenia. Schizophr Res 106: 115–124.
  • Hubl D, Koenig T, Strik W, Federspiel A, Kreis R, Boesch C, Maier SE, Schroth G, Lovblad K, Dierks T ( 2004): Pathways that make voices: White matter changes in auditory hallucinations. Arch Gen Psychiatry 61: 658–668.
  • Jardri R, Pouchet A, Pins D, Thomas P ( 2010): Cortical activations during auditory verbal hallucinations in schizophrenia: A coordinate-based meta-analysis. Am J Psychiatry 168:73–81.
  • Johns LC, Nazroo JY, Bebbington P, Kuipers E ( 2002): Occurrence of hallucinatory experiences in a community sample and ethnic variations. Br J Psychiatry 180: 174–178.
  • Kay SR, Fiszbein A, Opler LA ( 1987): The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13: 261–276.
  • Mandl RC, Schnack HG, Luigjes J, van den Heuvel MP, Cahn W, Kahn RS, Hulshoff Pol HE ( 2010): Tract-based analysis of magnetization transfer ratio and diffusion tensor imaging of the frontal and frontotemporal connections in schizophrenia. Schizophr Bull 36: 778–787.
  • Mori S, Crain BJ, Chacko VP, van Zijl PC ( 1999): Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 45: 265–269.
    Direct Link:
  • Munoz Maniega S, Lymer GK, Bastin ME, Marjoram D, Job DE, Moorhead TW, Owens DG, Johnstone EC, McIntosh AM, Lawrie SM ( 2008): A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia. Schizophr Res 106: 132–139.
  • Nakamura M, McCarley RW, Kubicki M, Dickey CC, Niznikiewicz MA, Voglmaier MM, Seidman LJ, Maier SE, Westin CF, Kikinis R, Shenton ME ( 2005): Fronto-temporal disconnectivity in schizotypal personality disorder: A diffusion tensor imaging study. Biol Psychiatry 58: 468–478.
  • Oldfield RC ( 1971): The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia 9: 97–113.
  • Raine A ( 1991): The SPQ: A scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull 17: 555–564.
  • Rosenberger G, Kubicki M, Nestor PG, Connor E, Bushell GB, Markant D, Niznikiewicz M, Westin CF, Kikinis R, Saykin J, McCarley RW, Shenton ME ( 2008): Age-related deficits in fronto-temporal connections in schizophrenia: A diffusion tensor imaging study. Schizophr Res 102: 181–188.
  • Seok JH, Park HJ, Chun JW, Lee SK, Cho HS, Kwon JS, Kim JJ ( 2007): White matter abnormalities associated with auditory hallucinations in schizophrenia: A combined study of voxel-based analyses of diffusion tensor imaging and structural magnetic resonance imaging. Psychiatry Res 156: 93–104.
  • Shergill SS, Brammer MJ, Williams SC, Murray RM, McGuire PK ( 2000): Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging. Arch Gen Psychiatry 57: 1033–1038.
  • Shergill SS, Kanaan RA, Chitnis XA, O'Daly O, Jones DK, Frangou S, Williams SC, Howard RJ, Barker GJ, Murray RM, McGuire P ( 2007): A diffusion tensor imaging study of fasciculi in schizophrenia. Am J Psychiatry 164: 467–473.
  • Sommer IE, de Weijer AD, Daalman K, Neggers SF, Somers M, Kahn RS, Slotema CW, Blom JD, Hoek HW, Aleman A ( 2007): Can fMRI-guidance improve the efficacy of rTMS treatment for auditory verbal hallucinations? Schizophr Res 93: 406–408.
  • Sommer IE, Diederen KM, Blom JD, Willems A, Kushan L, Slotema K, Boks MP, Daalman K, Hoek HW, Neggers SF, Kahn RS ( 2008): Auditory verbal hallucinations predominantly activate the right inferior frontal area. Brain 131: 3169–3177.
  • Sommer IE, Daalman K, Rietkerk T, Diederen KM, Bakker S, Wijkstra J, Boks MP ( 2010): Healthy individuals with auditory verbal hallucinations: who are they? Psychiatric assessments of a selected sample of 103 subjects. Schizophr Bull 36: 633–641.
  • Tien AY ( 1991): Distributions of hallucinations in the population. Soc Psychiatry Psychiatr Epidemiol 26: 287–292.
  • van Buchem MA, McGowan JC, Grossman RI ( 1999): Magnetization transfer histogram methodology: Its clinical and neuropsychological correlates. Neurology 53: S23–S28.
  • Wakana S, Jiang H, Nagae-Poetscher LM, van Zijl PC, Mori S ( 2004): Fiber tract-based atlas of human white matter anatomy. Radiology 230: 77–87.
  • Whitford TJ, Mathalon DH, Shenton ME, Roach BJ, Bammer R, Adcock RA, Bouix S, Kubicki M, De SJ, Rausch AC, Schneiderman JS, Ford JM ( 2010): Electrophysiological and diffusion tensor imaging evidence of delayed corollary discharges in patients with schizophrenia. Psychol Med 41:959–969.
  • Wolff SD, Balaban RS ( 1994): Magnetization transfer imaging: Practical aspects and clinical applications. Radiology 192: 593–599.
View Full Article with Supporting Information (HTML) Get PDF (3940K)