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Quantitative effect of the neonatal fontanel on synthetic near infrared spectroscopy measurements

Authors

  • Mathieu Dehaes,

    Corresponding author
    1. GRAMFC, UPJV, EA 4293, Laboratoire de neurophysiologie, Amiens, France
    2. INSERM, UPMC Univ Paris 06, UMR-S 678, Laboratoire d'Imagerie Fonctionnelle (LIF), Paris, France
    3. INSERM, Université de Montréal, UPMC Univ Paris 06, LINeM, Laboratoire International de Neuroimagerie et Modélisation, Paris, France
    Current affiliation:
    1. Division of Newborn Medicine, Department of Medicine, Children's Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115
    • Division of Newborn Medicine, Department of Medicine, Children's Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115
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  • Kamran Kazemi,

    1. Department of Electrical and Electronics Engineering, Shiraz University of Technology, Shiraz, Iran
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  • Mélanie Pélégrini-Issac,

    1. INSERM, UPMC Univ Paris 06, UMR-S 678, Laboratoire d'Imagerie Fonctionnelle (LIF), Paris, France
    2. INSERM, Université de Montréal, UPMC Univ Paris 06, LINeM, Laboratoire International de Neuroimagerie et Modélisation, Paris, France
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  • Reinhard Grebe,

    1. GRAMFC, UPJV, EA 4293, Laboratoire de neurophysiologie, Amiens, France
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  • Habib Benali,

    1. INSERM, UPMC Univ Paris 06, UMR-S 678, Laboratoire d'Imagerie Fonctionnelle (LIF), Paris, France
    2. INSERM, Université de Montréal, UPMC Univ Paris 06, LINeM, Laboratoire International de Neuroimagerie et Modélisation, Paris, France
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  • Fabrice Wallois

    1. GRAMFC, UPJV, EA 4293, Laboratoire de neurophysiologie, Amiens, France
    2. GRAMFC, EA 4293, EFSN pédiatrique CHU Amiens Nord, France
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Abstract

Near infrared spectroscopy (NIRS) is a functional imaging technique allowing measurement of local cerebral oxygenation. This modality is particularly adapted to critically ill neonates, as it can be used at the bedside and is a suitable and noninvasive tool for carrying out longitudinal studies. However, NIRS is sensitive to the imaged medium and consequently to the optical properties of biological tissues in which photons propagate. In this study, the effect of the neonatal fontanel was investigated by predicting photon propagation using a probabilistic Monte Carlo approach. Two anatomical newborn head models were created from computed tomography and magnetic resonance images: (1) a realistic model including the fontanel tissue and (2) a model in which the fontanel was replaced by skull tissue. Quantitative change in absorption due to simulated activation was compared for the two models for specific regions of activation and optical arrays simulated in the temporal area. A correction factor was computed to quantify the effect of the fontanel and defined by the ratio between the true and recovered change. The results show that recovered changes in absorption were more precise when determined with the anatomical model including the fontanel. The results suggest that the fontanel should be taken into account in quantification of NIRS responses to avoid misinterpretation in experiments involving temporal areas, such as language or auditory studies. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.

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