Jonathan List and Thomas Duning contributed equally to this work.
Cortical plasticity is preserved in nondemented older individuals with severe ischemic small vessel disease†
Article first published online: 14 FEB 2012
Copyright © 2011 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 34, Issue 6, pages 1464–1476, June 2013
How to Cite
List, J., Duning, T., Kürten, J., Deppe, M., Wilbers, E. and Flöel, A. (2013), Cortical plasticity is preserved in nondemented older individuals with severe ischemic small vessel disease. Hum. Brain Mapp., 34: 1464–1476. doi: 10.1002/hbm.22003
- Issue published online: 15 APR 2013
- Article first published online: 14 FEB 2012
- Manuscript Accepted: 3 NOV 2011
- Manuscript Revised: 31 OCT 2011
- Manuscript Received: 18 JUL 2011
- Deutsche Forschungsgemeinschaft. Grant Numbers: Fl 379-4/2,, Fl 379-8/1, DFG-Exc 257
- Bundesministerium für Bildung und Forschung. Grant Numbers: FKZ 0315673A,, 01EO0801
Additional Supporting Information may be found in the online version of this article.
|HBM_22003_sm_SuppFig1.tif||4125K||Supplementary Figure 1: SPM “glass brain” representation (A) and statistical FA maps superimposed on an average FA template (B and C) showing clusters of correlations between MEP changes after PAS and decreased FA values in the SVD group (p < 0.001, minimum of 20 continuous voxels, corrected for multiple comparison). The analysis was adjusted for age and the mean FA of the ROI “corticospinal tract” to rule out an unspecific effect, e.g. a causal relationship between FA deficits of areas more closely related to motor cortex plasticity. Although the significant clusters were less distinct and widespread after the adjustment for corticospinal FA changes, the association between greater rapid-onset cortical plasticity and lower FA values symmetrically in the parahippocampal area and in the posterior part of the corpus callosum (red circles) was still preserved [using the same p-values for statistical significance].|
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