N.C. and E.L. have contributed equally to this work.
Right, left, and center: How does cerebral asymmetry mix with callosal connectivity?
Article first published online: 15 MAR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 34, Issue 7, pages 1728–1736, July 2013
How to Cite
Cherbuin, N., Luders, E., Chou, Y.-Y., Thompson, P. M., Toga, A. W. and Anstey, K. J. (2013), Right, left, and center: How does cerebral asymmetry mix with callosal connectivity?. Hum. Brain Mapp., 34: 1728–1736. doi: 10.1002/hbm.22022
- Issue published online: 14 JUN 2013
- Article first published online: 15 MAR 2012
- Manuscript Accepted: 28 NOV 2011
- Manuscript Revised: 13 NOV 2011
- Manuscript Received: 16 MAY 2011
- NHMRC of Australia. Grant Numbers: 973302, 179805, 157125
- NHMRC Research Fellowship. Grant Numbers: 471501, 1002560
- NIH. Grant Number: U54 RR021813
- National Center for Research Resources (NCRR), NIH. Grant Numbers: P41 RR013642, M01 RR000865
- NIBIB. Grant Numbers: R01 EB007813, R01 EB008281, R01 EB008432
- NICHHD. Grant Number: R01 HD050735
- NIA. Grant Number: R01 AG020098
- white matter;
- planum temporale;
- supramarginal gyrus;
- pars opercularis;
- temporal gyrus
Background: Prior research has shown that cerebral asymmetry is associated with differences in corpus callosum connectivity. Such associations were detected in histological and anatomical studies investigating callosal fiber size and density, in neuroimaging investigations based on structural and diffusion tensor imaging, as well as in neuropsychological experiments. However, little is known about typical associations between these factors, and even less about the relative influences of magnitude and direction of cerebral asymmetries. Here, we investigated relationships between callosal connectivity and cerebral asymmetry using precise measures of callosal thickness and selected cerebral structures. We considered both the direction and magnitude of the asymmetries. Methods: Associations between cerebral asymmetry and callosal thickness were investigated in 348 cognitively healthy older individuals. Results: The magnitude and direction of cerebral lateralization were significant independent predictors of callosal thickness. However, associations were small. Leftward asymmetry and increased magnitude of asymmetry were generally associated with increased callosal thickness, mostly in the callosal midbody and isthmus. Conclusions: When a large sample of normal individuals is considered, cerebral asymmetries are only subtly associated with callosal thickness. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.