Episodic autobiographical memory in amnestic mild cognitive impairment: What are the neural correlates?
Article first published online: 16 MAR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 34, Issue 8, pages 1811–1825, August 2013
How to Cite
Bastin, C., Feyers, D., Jedidi, H., Bahri, M. A., Degueldre, C., Lemaire, C., Collette, F. and Salmon, E. (2013), Episodic autobiographical memory in amnestic mild cognitive impairment: What are the neural correlates?. Hum. Brain Mapp., 34: 1811–1825. doi: 10.1002/hbm.22032
- Issue published online: 8 JUL 2013
- Article first published online: 16 MAR 2012
- Manuscript Received: 20 JUN 2012
- Manuscript Accepted: 5 DEC 2011
- Manuscript Revised: 22 NOV 2011
- Inter-University Attraction Pole. Grant Number: P6/29
- French Community of Belgium. Grant Number: ARC 06/11-340
- European Community projects Nest-DD and EC – FP6-project DiMI. Grant Number: LSHB-CT-2005-512146; Contract grant sponsors: University of Liège, Belgian National Funds for Scientific Research.
- Unknown funding agency
- autobiographical memory;
- episodic memory;
- mild cognitive impairment;
Autobiographical memory in amnestic Mild Cognitive Impairment (aMCI) is characterized by impaired retrieval of episodic memories, but relatively preserved personal semantic knowledge. This study aimed to identify (via FDG-PET) the neural substrates of impaired episodic specificity of autobiographical memories in 35 aMCI patients compared with 24 healthy elderly controls. Significant correlations between regional cerebral activity and the proportion of episodic details in autobiographical memories from two life periods were found in specific regions of an autobiographical brain network. In aMCI patients, more than in controls, specifically episodic memories from early adulthood were associated with metabolic activity in the cuneus and in parietal regions. We hypothesized that variable retrieval of episodic autobiographical memories in our aMCI patients would be related to their variable capacity to reactivate specific sensory-perceptual and contextual details of early adulthood events linked to reduced (occipito-parietal) visual imagery and less efficient (parietal) attentional processes. For recent memories (last year), a correlation emerged between the proportion of episodic details and activity in lateral temporal regions and the temporo-parietal junction. Accordingly, variable episodic memory for recent events may be related to the efficiency of controlled search through general events likely to provide cues for the retrieval of episodic details and to the ability to establish a self perspective favouring recollection. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.