Frank Seifert and Nadine Schuberth contributed equally to this work.
Brain activity during sympathetic response in anticipation and experience of pain
Article first published online: 22 MAR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 34, Issue 8, pages 1768–1782, August 2013
How to Cite
Seifert, F., Schuberth, N., De Col, R., Peltz, E., Nickel, F. T. and Maihöfner, C. (2013), Brain activity during sympathetic response in anticipation and experience of pain. Hum. Brain Mapp., 34: 1768–1782. doi: 10.1002/hbm.22035
- Issue published online: 8 JUL 2013
- Article first published online: 22 MAR 2012
- Manuscript Accepted: 5 DEC 2011
- Manuscript Revised: 19 OCT 2011
- Manuscript Received: 9 MAR 2011
- “German Research Network on Neuropathic Pain” (German Federal Ministry of Education and Research; BMBF)
- German Research Foundation (KFO130)
- autonomic nervous system;
- neuropathic pain;
- somatosensory system
Pain is a multidimensional phenomenon with sensory, affective, and autonomic components. Here, we used parametric functional magnetic resonance imaging (fMRI) to correlate regional brain activity with autonomic responses to (i) painful stimuli and to (ii) anticipation of pain. The autonomic parameters used for correlation were (i) skin blood flow (SBF) and (ii) skin conductance response (SCR). During (i) experience of pain and (ii) anticipation of pain, activity in the insular cortex, anterior cingulate cortex (ACC), prefrontal cortex (PFC), posterior parietal cortex (PPC), secondary somatosensory cortex (S2), thalamus, and midbrain correlated with sympathetic outflow. A conjunction analysis revealed a common central sympathetic network for (i) pain experience and (ii) pain anticipation with similar correlations between brain activity and sympathetic parameters in the anterior insula, prefrontal cortex, thalamus, midbrain, and temporoparietal junction. Therefore, we here describe shared central neural networks involved in the central autonomic processing of the experience and anticipation of pain. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.