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Additional Supporting Information may be found in the online version of this article.

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HBM_22038_sm_SuppTab1.docx18KSupporting Information Table 1. List of medications and dosages (mg/day) for medicated OCD (mOCD) and medicated patient control (mPC) groups. SSRIs = selective-serotonin reuptake inhibitors; SNRIs = serotonin-norepinephrine reuptake inhibitors; TCAs = tricycle antidepressants. All subjects were taking a serotonin reuptake inhibitor (SSRI or SNRI). Five mOCD and 4 mPC subjects were taking more than one medication (not including benzodiazepines, which were taken as needed and omitted on the day of testing). ± Dosing information not available for one subject.
HBM_22038_sm_SuppTab2.docx32KSupporting Information Table 2. Within-group effects for the first piece of evidence on Certain vs. Uncertain sequences. There were no significantly active regions for the contrast of Uncertain > Certain trials for OCD patients. aI/fO = anterior insula/frontal operculum; DMPFC = dorsomedial prefrontal cortex; MFG = middle frontal gyrus; SFG = superior frontal gyrus; IFG = inferior frontal gyrus; aPFC = anterior prefrontal cortex; IPL = inferior parietal lobule; dACC = dorsal anterior cingulate cortex; SMA = supplementary motor area; PCC = posterior cingulate cortex; STG = superior temporal gyrus, PG = parahippocampal gyrus; OFC = orbitofrontal cortex; VMPFC = ventromedial prefrontal cortex; MTG = middle temporal cortex, aMFC = anterior medial frontal cortex. Superscript letters designate coordinates located within the same cluster.
HBM_22038_sm_SuppTab3.docx34KSupporting Information Table 3. Within-group effects for accumulating evidence that increases vs. decreases certainty. There were no regions uniquely activated by controls for the increase > decrease contrast or for OCD patients for the decrease > increase contrast. IPL = inferior parietal lobule; STG = superior temporal gyrus; SMA = supplementary motor area; aMFC = anterior medial frontal cortex; VMPFC = ventromedial prefrontal cortex; MTG = middle temporal gyrus; MFG = middle frontal gyrus; IFG = inferior frontal gyrus; dACC = dorsal anterior cingulate cortex; SPL = superior parietal lobule; aI/fO = anterior insula/frontal operculum; ITG = inferior temporal gyrus. Superscript letters designate coordinates located within the same cluster.
HBM_22038_sm_SuppTab4.docx40KSupporting Information Table 4. Within-group effects for accumulating evidence that increases vs. maintains certainty. There were no regions uniquely activated by OCD patients for the increase > maintain contrast. IPL = inferior parietal lobule; SFG = superior frontal gyrus; MFG = middle frontal gyrus; sSMA = supplementary motor area; aI/fO = anterior insula/frontal operculum; IFG = inferior frontal gyrus; PCC = posterior cingulate cortex; MTG = middle temporal cortex; DMPFC = dorsomedial prefrontal cortex; aMFC = anterior medial frontal cortex; VMPFC = ventromedial prefrontal cortex; ACC = anterior cingulate cortex; PG = parahippocampal gyrus; STG = superior temporal gyrus; ITG = inferior temporal gyrus; OFC = orbitofrontal cortex. Superscript letters designate coordinates located within the same cluster.
HBM_22038_sm_SuppTab5.docx46KSupporting Information Table 5. Within-group effects for accumulating evidence that decreases vs. maintains certainty. There were no regions uniquely activated by OCD patients for the decrease > maintain contrast. aPFC = anterior prefrontal cortex; MFG = middle frontal gyrus; aI/fO = anterior insula/frontal operculum; SMA = supplementary motor area; dorsal anterior cingulate cortex = dACC; IPL = inferior parietal lobule; IFG = inferior frontal gyrus; ITG = inferior temporal gyrus; MTG = middle temporal cortex; PCC = posterior cingulate cortex; PG = parahippocampal gyrus; DMPFC = dorsomedial prefrontal cortex; aMFC = anterior medial frontal cortex; VMPFC = ventromedial prefrontal cortex; STG = superior temporal gyrus; OFC = orbitofrontal cortex. Superscript letters designate coordinates located within the same cluster.
HBM_22038_sm_SuppTab6.docx76KSupporting Information Table 6. Regions where OCD patients > control subjects for the first piece of evidence on Certain as compared to Uncertain sequences, corrected for multiple comparisons across the whole-brain at p < .05. BA = Brodmann's area(s); k = number of voxels; Z = maximum z-score; R = right; L = left; PG = Parahippocampal gyrus;, MTG = middle temporal gyrus; STG = superior temporal gyrus; IPL = inferior parietal lobule; xcoordinates are in MNI space. ± Significant at trend level (p < .1). There were no regions where controls > OCD at the current threshold.
HBM_22038_sm_SuppFig1.tif14852KSupporting Information Figure 1. Within-group activations for a) first piece of evidence > implicit baseline on Certain sequences, b) first piece of evidence > implicit baseline on Uncertain sequences, and c) first piece of evidence on Certain > Uncertain sequences. OCD patients are shown in blue, controls are shown in red, and overlap shown in pink. Color bars represent t scores.
HBM_22038_sm_SuppFig2.tif9487KSupporting Information Figure 2. Within-group a) activations and b) deactivations for accumulating evidence (draws 2, 3, and 4) that maintains maximal certainty on Certain sequences compared to implicit baseline. OCD patients are shown in blue, controls are shown in red, and overlap shown in pink. Color bars represent t scores.
HBM_22038_sm_SuppFig3.tif9485KSupporting Information Figure 3. Within-group a) activations and b) deactivations for accumulating evidence (draws 2, 3, and 4) that increases certainty on Uncertain sequences compared to implicit baseline. OCD patients are shown in blue, controls are shown in red, and overlap shown in pink. Color bars represent t scores.
HBM_22038_sm_SuppFig4.tif9281KSupporting Information Figure 4. Within-group a) activations and b) deactivations for accumulating evidence (draws 2, 3, and 4) that decreases certainty on Uncertain sequences compared to implicit baseline. OCD patients are shown in blue, controls are shown in red, and overlap shown in pink. Color bars represent t scores.
HBM_22038_sm_SuppFig5.tif8998KSupporting Information Figure 5. Within-group activations for accumulating evidence (draws 2, 3, and 4) that increases > decreases certainty and b) decreases > increases certainty on Uncertain sequences. OCD patients are shown in blue, controls are shown in red, and overlap shown in pink. Color bars represent t scores.
HBM_22038_sm_SuppInfo.docx31KSupporting Information

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