Neural response to emotional stimuli during experimental human endotoxemia
Article first published online: 28 MAR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Human Brain Mapping
How to Cite
Kullmann, J. S., Grigoleit, J.-S., Lichte, P., Kobbe, P., Rosenberger, C., Banner, C., Wolf, O. T., Engler, H., Oberbeck, R., Elsenbruch, S., Bingel, U., Forsting, M., Gizewski, E. R. and Schedlowski, M. (2012), Neural response to emotional stimuli during experimental human endotoxemia. Hum. Brain Mapp.. doi: 10.1002/hbm.22063
- Article first published online: 28 MAR 2012
- Manuscript Accepted: 25 JAN 2012
- Manuscript Revised: 12 DEC 2011
- Manuscript Received: 13 JUL 2011
- German Research Foundation. Grant Number: Sche 341/14-1
- emotional processing;
- sickness behavior;
- peripheral inflammation
Increases in peripheral cytokines during acute inflammation may affect various neuropsychological functions. The aim of this functional magnetic resonance imaging (fMRI) study was to investigate the effects of acute endotoxemia on mood and the neural response to emotionally aversive visual stimuli in healthy human subjects. In a double-blind, randomized crossover study, 18 healthy males received a bolus injection of bacterial lipopolysaccharide (LPS; 0.4 ng/kg) or saline. Plasma levels of pro- and anti-inflammatory cytokines and cortisol as well as mood ratings were analyzed together with the blood-oxygen-level dependent (BOLD) response during the presentation of aversive versus neutral pictures. Endotoxin administration induced pronounced transient increases in plasma levels of TNF-α, IL-1ra, IL-6, IL-10, and cortisol. Positive mood was decreased and state anxiety increased. In addition, activation of right inferior orbitofrontal cortex (OFC) in response to emotional visual stimuli was significantly increased in the LPS condition. Increased prefrontal activation during the presentation of emotional material may reflect enhanced cognitive regulation of emotions as an adaptive response during an acute inflammation. These findings may have implications for the putative role of inflammatory processes in the pathophysiology of depression. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.