Brain plasticity in the motor network is correlated with disease progression in amyotrophic lateral sclerosis
Version of Record online: 28 MAR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 34, Issue 10, pages 2391–2401, October 2013
How to Cite
Poujois, A., Schneider, F. C., Faillenot, I., Camdessanché, J.-P., Vandenberghe, N., Thomas-Antérion, C. and Antoine, J.-C. (2013), Brain plasticity in the motor network is correlated with disease progression in amyotrophic lateral sclerosis. Hum. Brain Mapp., 34: 2391–2401. doi: 10.1002/hbm.22070
- Issue online: 12 SEP 2013
- Version of Record online: 28 MAR 2012
- Manuscript Accepted: 13 FEB 2012
- Manuscript Revised: 21 DEC 2011
- Manuscript Received: 4 JUN 2011
- Centre Hospitalier Universitaire, Saint-Etienne, France
- controlateral activation;
Objective: To test the influence of functional cerebral reorganization in amyotrophic lateral sclerosis (ALS) on disease progression. Methods: Nineteen predominantly right-handed ALS patients and 21 controls underwent clinical evaluation, functional Magnetic Resonance Imaging (fMRI), and diffusion tensor imaging. Patients were clinically re-evaluated 1 year later and followed until death. For fMRI, subjects executed and imagined a simple hand-motor task. Between-group comparisons were performed, and correlations were searched with motor deficit arm Medical Research Council (MRC) score, disease progression ALS Functional Rating Scale (ALSFRS), and survival time. Results: By the MRC score, the hand strength was lowered by 12% in the ALS group predominating on the right side in accordance with an abnormal fractional anisotropy (FA) limited to the left corticospinal tract (37.3% reduction vs. controls P < 0.01). Compared to controls, patients displayed overactivations in the controlateral parietal (P < 0.004) and somatosensory (P < 0.004) cortex and in the ipsilateral parietal (P < 0.01) and somatosensory (P < 0.01) cortex to right-hand movement. Movement imagination gave similar results while no difference occurred with left-hand tasks. Stepwise regression analysis corrected for multiple comparisons showed that controlateral parietal activity was inversely correlated with disease progression (R2 = 0.43, P = 0.001) and ipsilateral somatosensory activations with the severity of the right-arm deficit (R2 = 0.48, P = 0.001). Conclusions: Cortical Blood Oxygen Level Dependent (BOLD) signal changes occur in the brain of ALS patients during a simple hand-motor task when the motor deficit is still moderate. It is correlated with the rate of disease progression suggesting that brain functional rearrangement in ALS may have prognostic implications. Hum Brain Mapp 34:2391–2401, 2013. © 2012 Wiley Periodicals, Inc.