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(Still) longing for food: Insulin reactivity modulates response to food pictures

Authors

  • Nils B. Kroemer,

    1. Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany
    2. Neuroimaging Center, Department of Psychology, Technische Universität Dresden, Dresden, Germany
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  • Lena Krebs,

    1. Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
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  • Andrea Kobiella,

    1. Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany
    2. Neuroimaging Center, Department of Psychology, Technische Universität Dresden, Dresden, Germany
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  • Oliver Grimm,

    1. Department of Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
    2. Department of Neuropsychology, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
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  • Sabine Vollstädt-Klein,

    1. Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany
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  • Uta Wolfensteller,

    1. Neuroimaging Center, Department of Psychology, Technische Universität Dresden, Dresden, Germany
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  • Ricarda Kling,

    1. Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany
    2. Neuroimaging Center, Department of Psychology, Technische Universität Dresden, Dresden, Germany
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  • Martin Bidlingmaier,

    1. Department of Internal Medicine, Section of Endocrinology, Medizinische Klinik Campus Innenstadt, LMU Munich, Germany
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  • Ulrich S. Zimmermann,

    1. Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany
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  • Michael N. Smolka

    Corresponding author
    1. Neuroimaging Center, Department of Psychology, Technische Universität Dresden, Dresden, Germany
    • Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany
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Section of Systems Neuroscience, Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Würzburger Str. 35, 01187 Dresden, Germany. E-mail: michael.smolka@tu-dresden.de

Abstract

Overweight and obesity pose serious challenges to public health and are promoted by our food-rich environment. We used functional magnetic resonance imaging (fMRI) to investigate reactivity to food cues after overnight fasting and following a standardized caloric intake (i.e., a 75 g oral glucose tolerance test, OGTT) in 26 participants (body mass index, BMI between 18.5 and 24.9 kg m−2). They viewed pictures of palatable food and low-level control stimuli in a block design and rated their current appetite after each block. Compared to control pictures, food pictures activated a large bilateral network typically involved in homeostatically and hedonically motivated food processing. Glucose ingestion was followed by decreased activation in the basal ganglia and paralimbic regions and increased activation in parietal and occipital regions. Plasma level increases in insulin correlated with cue-induced appetite at the neural and behavioral level. High insulin increases were associated with reduced activation in various bilateral regions including the fusiform gyrus, the superior temporal gyrus, the medial frontal gyrus, and the limbic system in the right hemisphere. In addition, they were accompanied by lower subjective appetite ratings following food pictures and modulated the neural response associated with it (e.g., in the fusiform gyrus). We conclude that individual insulin reactivity is critical to reduce food-cue responsivity after an initial energy intake and thereby may help to counteract overeating. Hum Brain Mapp 34:2367–2380, 2013. © 2012 Wiley Periodicals, Inc.

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