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Correlation between high-sensitivity C-reactive protein and brain gray matter volume in healthy elderly subjects

Authors

  • Yasuyuki Taki,

    Corresponding author
    • Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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  • Benjamin Thyreau,

    1. Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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  • Shigeo Kinomura,

    1. Department of Nuclear Medicine & Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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  • Kazunori Sato,

    1. Department of Nuclear Medicine & Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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  • Ryoi Goto,

    1. Department of Nuclear Medicine & Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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  • Kai Wu,

    1. Department of Nuclear Medicine & Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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  • Masako Kakizaki,

    1. Division of Epidemiology, Department of Public Health & Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
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  • Ichiro Tsuji,

    1. Division of Epidemiology, Department of Public Health & Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
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  • Ryuta Kawashima,

    1. Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    2. Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    3. Smart Ageing International Research Centre, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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  • Hiroshi Fukuda

    1. Department of Nuclear Medicine & Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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Division of Developmental Cognitive Neuroscience, Institute of Development, Aging & Cancer, Tohoku University, 4-1 Seiryocho, Aobaku, 980-8575 Sendai, Japan. E-mail: ytaki@idac.tohoku.ac.jp

Abstract

Although elevated serum high-sensitivity C-reactive protein (hsCRP) is related to atherosclerosis, brain infarction, and cognitive decline, it has not been clarified whether increased hsCRP is associated with the decline in brain gray matter volume. Therefore, the purpose of this study was to determine the relationship between hsCRP levels and brain regional gray matter volume using brain magnetic resonance imaging (MRI) data from 109 community-dwelling healthy elderly subjects. Brain MRIs were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra (DARTEL) procedure. We found a significant negative correlation between regional gray matter volume of the posterior and lateral aspects of the left temporal cortex and hsCRP level after adjusting for age, gender, and intracranial volume. Our results suggest that subjects who have mild inflammation related to arteriosclerosis have decreased regional gray matter volume in the posterior and lateral aspects of the left temporal cortex. Thus, preventing the progression of arteriosclerosis may be important for preventing a decrease in gray matter volume in healthy elderly subjects. Hum Brain Mapp 34:2418–2424, 2013. © 2012 Wiley Periodicals, Inc.

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