J.T. Dunn is senior author for the PET component of the study.
Regional cerebral blood flow and FDG uptake in asymptomatic HIV-1 men
Article first published online: 12 APR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 34, Issue 10, pages 2484–2493, October 2013
How to Cite
Towgood, K. J., Pitkanen, M., Kulasegaram, R., Fradera, A., Soni, S., Sibtain, N., Reed, L. J., Bradbeer, C., Barker, G. J., Dunn, J. T., Zelaya, F. and Kopelman, M. D. (2013), Regional cerebral blood flow and FDG uptake in asymptomatic HIV-1 men. Hum. Brain Mapp., 34: 2484–2493. doi: 10.1002/hbm.22078
- Issue published online: 12 SEP 2013
- Article first published online: 12 APR 2012
- Manuscript Accepted: 14 FEB 2012
- Manuscript Revised: 13 FEB 2012
- Manuscript Received: 13 DEC 2011
- Guy's and St Thomas's Charity
- glucose uptake;
Despite advances in the treatment of patients with human immunodeficiency virus (HIV), HIV-associated neurocognitive disorder occurs in 15–50% of HIV-infected individuals, and may become more apparent as ageing advances. In the present study we investigated regional cerebral blood flow (rCBF) and regional cerebral metabolic rate of glucose uptake (rCMRglc) in medically and psychiatrically stable HIV-1-infected participants in two age-groups. Positron emission tomography (PET) and magnetic resonance imaging (MRI)-based arterial spin labeling (ASL) were used to measure rCMRglc and rCBF, respectively, in 35 HIV-infected participants and 37 HIV-negative matched controls. All participants were currently asymptomatic with undetectable HIV-1 viral loads, without medical or psychiatric comorbidity, alcohol or substance misuse, stable on medication for at least 6 months before enrolment in the study. We found significant age effects on both ASL and PET with reduced rCBF and rCMRglc in related frontal brain regions, and consistent, although small, reductions in rCBF and rCMRglc in the anterior cingulate cortex (ACC) in HIV, a finding of potential clinical significance. There was no significant interaction between HIV status and the ageing process, and no significant HIV-related changes elsewhere in the brain on PET or ASL. This is the first paper to combine evidence from ASL and PET method in HIV participants. These finding provide evidence of crossvalidity between the two techniques, both in ageing and a clinical condition (HIV). Hum Brain Mapp 34:2484–2493, 2013. © 2012 Wiley Periodicals, Inc.