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Alterations of the salience network in obesity: A resting-state fMRI study

Authors

  • Isabel García-García,

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Institute for Brain, Cognition and Behaviour (IR3C), Barcelona, Spain
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  • María Ángeles Jurado,

    Corresponding author
    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Institute for Brain, Cognition and Behaviour (IR3C), Barcelona, Spain
    3. Grup de Recerca Consolidat en Neuropsicologia (SGR0941), Barcelona, Spain
    • Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Passeig de la Vall d'Hebron 171, 08035 Barcelona, Spain. E-mail: majurado@ub.edu

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  • Maite Garolera,

    1. Grup de Recerca Consolidat en Neuropsicologia (SGR0941), Barcelona, Spain
    2. Neuropsychology Unit, Hospital de Terrassa, Consorci Sanitari de Terrassa, Terrassa, Spain
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  • Bàrbara Segura,

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Grup de Recerca Consolidat en Neuropsicologia (SGR0941), Barcelona, Spain
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  • Roser Sala-Llonch,

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Grup de Recerca Consolidat en Neuropsicologia (SGR0941), Barcelona, Spain
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  • Idoia Marqués-Iturria,

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Institute for Brain, Cognition and Behaviour (IR3C), Barcelona, Spain
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  • Roser Pueyo,

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Institute for Brain, Cognition and Behaviour (IR3C), Barcelona, Spain
    3. Grup de Recerca Consolidat en Neuropsicologia (SGR0941), Barcelona, Spain
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  • María José Sender-Palacios,

    1. CAP Terrassa Nord, Consorci Sanitari de Terrassa, Terrassa, Spain
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  • Maria Vernet-Vernet,

    1. CAP Terrassa Nord, Consorci Sanitari de Terrassa, Terrassa, Spain
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  • Ana Narberhaus,

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Institute for Brain, Cognition and Behaviour (IR3C), Barcelona, Spain
    3. Grup de Recerca Consolidat en Neuropsicologia (SGR0941), Barcelona, Spain
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  • Mar Ariza,

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Institute for Brain, Cognition and Behaviour (IR3C), Barcelona, Spain
    3. Grup de Recerca Consolidat en Neuropsicologia (SGR0941), Barcelona, Spain
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  • Carme Junqué

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Grup de Recerca Consolidat en Neuropsicologia (SGR0941), Barcelona, Spain
    3. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
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Abstract

Obesity is a major health problem in modern societies. It has been related to abnormal functional organization of brain networks believed to process homeostatic (internal) and/or salience (external) information. This study used resting-state functional magnetic resonance imaging analysis to delineate possible functional changes in brain networks related to obesity. A group of 18 healthy adult participants with obesity were compared with a group of 16 lean participants while performing a resting-state task, with the data being evaluated by independent component analysis. Participants also completed a neuropsychological assessment. Results showed that the functional connectivity strength of the putamen nucleus in the salience network was increased in the obese group. We speculate that this abnormal activation may contribute to overeating through an imbalance between autonomic processing and reward processing of food stimuli. A correlation was also observed in obesity between activation of the putamen nucleus in the salience network and mental slowness, which is consistent with the notion that basal ganglia circuits modulate rapid processing of information. Hum Brain Mapp 34:2786–2797, 2013. © 2012 Wiley Periodicals, Inc.

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