Keeping the body in mind: Insula functional organization and functional connectivity integrate interoceptive, exteroceptive, and emotional awareness
Article first published online: 13 JUN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 34, Issue 11, pages 2944–2958, November 2013
How to Cite
Simmons, W. K., Avery, J. A., Barcalow, J. C., Bodurka, J., Drevets, W. C. and Bellgowan, P. (2013), Keeping the body in mind: Insula functional organization and functional connectivity integrate interoceptive, exteroceptive, and emotional awareness. Hum. Brain Mapp., 34: 2944–2958. doi: 10.1002/hbm.22113
- Issue published online: 22 OCT 2013
- Article first published online: 13 JUN 2012
- Manuscript Accepted: 3 APR 2012
- Manuscript Revised: 8 MAR 2012
- Manuscript Received: 23 NOV 2011
- Oklahoma Health Research Award, Oklahoma Center for the Advancement of Science and Technology. Grant Number: HR10-141
- The William K. Warren Foundation
- Laureate Institute for Brain Research
Relatively discrete experimental literatures have grown to support the insula's role in the domains of interoception, focal exteroceptive attention and cognitive control, and the experience of anxiety, even as theoretical accounts have asserted that the insula is a critical zone for integrating across these domains. Here we provide the first experimental demonstration that there exists a functional topography across the insula, with distinct regions in the same participants responding in a highly selective fashion for interoceptive, exteroceptive, and affective processing. Although each insular region is associated with areas of differential resting state functional connectivity relative to the other regions, overall their functional connectivity profiles are quite similar, thereby providing a map of how interoceptive, exteroceptive, and emotional awareness are integrated within the insular cortex. Hum Brain Mapp 34:2944–2958, 2013. © 2012 Wiley Periodicals, Inc.