S.X. Guo, K.M. Kendrick, and R.J. Yu contributed equally to this work.
Key functional circuitry altered in schizophrenia involves parietal regions associated with sense of self
Article first published online: 24 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 35, Issue 1, pages 123–139, January 2014
How to Cite
Guo, S., Kendrick, K. M., Yu, R., Wang, H.-L. S. and Feng, J. (2014), Key functional circuitry altered in schizophrenia involves parietal regions associated with sense of self. Hum. Brain Mapp., 35: 123–139. doi: 10.1002/hbm.22162
- Issue published online: 9 DEC 2013
- Article first published online: 24 SEP 2012
- Manuscript Accepted: 15 JUN 2012
- Manuscript Revised: 13 JUN 2012
- Manuscript Received: 16 MAR 2012
- National Nature Science Foundation of China. Grant Numbers: 10901049, 11271121
- Key Laboratory of Computational and Stochastic Mathematics and Its Application of Hunan province. Grant Number: 11K038
- excellent talent of Hunan Normal University. Grant Number: ET11001
- National Centre for Mathematics and Interdisciplinary Science (NCMIS) in Chinese Academy of Sciences
- functional connectivity;
- partial correlation;
There is still no clear consensus as to which of the many functional and structural changes in the brain in schizophrenia are of most importance, although the main focus to date has been on those in the frontal and cingulate cortices. In the present study, we have used a novel holistic approach to identify brain-wide functional connectivity changes in medicated schizophrenia patients, and functional connectivity changes were analyzed using resting-state fMRI data from 69 medicated schizophrenia patients and 62 healthy controls. As far as we are aware, this is the largest population reported in the literature for a resting-state study. Voxel-based morphometry was also used to investigate gray and white matter volume changes. Changes were correlated with illness duration/symptom severity and a support vector machine analysis assessed predictive validity. A network involving the inferior parietal lobule, superior parietal gyrus, precuneus, superior marginal, and angular gyri was by far the most affected (68% predictive validity compared with 82% using all connections) and different components correlated with illness duration and positive and negative symptom severity. Smaller changes occurred in emotional memory and sensory and motor processing networks along with weakened interhemispheric connections. Our findings identify the key functional circuitry altered in schizophrenia involving the default network midline cortical system and the cortical mirror neuron system, both playing important roles in sensory and cognitive processing and particularly self-processing, all of which are affected in this disorder. Interestingly, the functional connectivity changes with the strongest links to schizophrenia involved parietal rather than frontal regions. Hum Brain Mapp 35:123–139, 2014. © 2012 Wiley Periodicals, Inc.