Jukka Remes ideated the subject-wise spatial concatenation of ICA maps before permutation tests as a procedure to account for multiple comparisons at high-model orders.
Altered resting-state activity in seasonal affective disorder
Article first published online: 15 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 35, Issue 1, pages 161–172, January 2014
How to Cite
Abou Elseoud, A., Nissilä, J., Liettu, A., Remes, J., Jokelainen, J., Takala, T., Aunio, A., Starck, T., Nikkinen, J., Koponen, H., Zang, Y.-F., Tervonen, O., Timonen, M. and Kiviniemi, V. (2014), Altered resting-state activity in seasonal affective disorder. Hum. Brain Mapp., 35: 161–172. doi: 10.1002/hbm.22164
- Issue published online: 9 DEC 2013
- Article first published online: 15 SEP 2012
- Manuscript Accepted: 19 JUN 2012
- Manuscript Revised: 15 MAY 2012
- Manuscript Received: 8 SEP 2011
- Academy of Finland. Grant Numbers: 111711, 123772
- Finnish Medical Foundation
- seasonal affective disorder;
- functional connectivity;
At present, our knowledge about seasonal affective disorder (SAD) is based mainly up on clinical symptoms, epidemiology, behavioral characteristics and light therapy. Recently developed measures of resting-state functional brain activity might provide neurobiological markers of brain disorders. Studying functional brain activity in SAD could enhance our understanding of its nature and possible treatment strategies. Functional network connectivity (measured using ICA-dual regression), and amplitude of low-frequency fluctuations (ALFF) were measured in 45 antidepressant-free patients (39.78 ± 10.64, 30 ♀, 15 ♂) diagnosed with SAD and compared with age-, gender- and ethnicity-matched healthy controls (HCs) using resting-state functional magnetic resonance imaging. After correcting for Type 1 error at high model orders (inter-RSN correction), SAD patients showed significantly increased functional connectivity in 11 of the 47 identified RSNs. Increased functional connectivity involved RSNs such as visual, sensorimotor, and attentional networks. Moreover, our results revealed that SAD patients compared with HCs showed significant higher ALFF in the visual and right sensorimotor cortex. Abnormally altered functional activity detected in SAD supports previously reported attentional and psychomotor symptoms in patients suffering from SAD. Further studies, particularly under task conditions, are needed in order to specifically investigate cognitive deficits in SAD. Hum Brain Mapp 35:161–172, 2014. © 2012 Wiley Periodicals, Inc.