Reduced specificity of functional connectivity in the aging brain during task performance
Article first published online: 23 AUG 2012
Copyright © 2012 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 35, Issue 1, pages 319–330, January 2014
How to Cite
Geerligs, L., Maurits, N. M., Renken, R. J. and Lorist, M. M. (2014), Reduced specificity of functional connectivity in the aging brain during task performance. Hum. Brain Mapp., 35: 319–330. doi: 10.1002/hbm.22175
- Issue published online: 9 DEC 2013
- Article first published online: 23 AUG 2012
- Manuscript Accepted: 16 JUL 2012
- Manuscript Revised: 10 JUL 2012
- Manuscript Received: 30 MAR 2012
- functional connectivity;
- neural noise;
The importance of studying connectivity in the aging brain is increasingly recognized. Recent studies have shown that connectivity within the default mode network is reduced with age and have demonstrated a clear relation of these changes with cognitive functioning. However, research on age-related changes in other functional networks is sparse and mainly focused on prespecified functional networks. Using functional magnetic resonance imaging, we investigated age-related changes in functional connectivity during a visual oddball task in a range of functional networks. It was found that compared with young participants, elderly showed a decrease in connectivity between areas belonging to the same functional network. This was found in the default mode network and the somatomotor network. Moreover, in all identified networks, elderly showed increased connectivity between areas within these networks and areas belonging to different functional networks. Decreased connectivity within functional networks was related to poorer cognitive functioning in elderly. The results were interpreted as a decrease in the specificity of functional networks in older participants. Hum Brain Mapp 35:319–330, 2014. © 2012 Wiley Periodicals, Inc.