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Frequency-specific alternations in the amplitude of low-frequency fluctuations in schizophrenia

Authors

  • Rongjun Yu,

    1. Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena, California
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    • Rongjun Yu and Yi-Ling Chien contributed equally to this work.

  • Yi-Ling Chien,

    1. Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
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    • Rongjun Yu and Yi-Ling Chien contributed equally to this work.

  • Hsiao-Lan Sharon Wang,

    Corresponding author
    1. Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan
    • Correspondence to: Hsiao-Lan Sharon Wang, Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei 10016, Taiwan. E-mail: hsiaolanw@gmail.com or Wen-Yih Isaac Tseng, Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan 10016, E-mail: wytseng@ntu.edu.tw or Hai-Gwo Hwu, Graduate Institute of Brain and Mind Science and Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Department of Psychology, College of Science Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan 10016, E-mail: haigohwu@ntu.edu.tw

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  • Chih-Min Liu,

    1. Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    2. Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan
    3. Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan
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  • Chen-Chung Liu,

    1. Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
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  • Tzung-Jeng Hwang,

    1. Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    2. Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan
    3. Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan
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  • Ming H. Hsieh,

    1. Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    2. Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan
    3. Department of Psychiatry, National Taiwan University Hospital Yun-Lin Branch, Douliou City, Taiwan
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  • Hai-Gwo Hwu,

    Corresponding author
    1. Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    2. Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan
    3. Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan
    • Correspondence to: Hsiao-Lan Sharon Wang, Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei 10016, Taiwan. E-mail: hsiaolanw@gmail.com or Wen-Yih Isaac Tseng, Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan 10016, E-mail: wytseng@ntu.edu.tw or Hai-Gwo Hwu, Graduate Institute of Brain and Mind Science and Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Department of Psychology, College of Science Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan 10016, E-mail: haigohwu@ntu.edu.tw

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  • Wen-Yih Isaac Tseng

    Corresponding author
    1. Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan
    2. Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan
    3. Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan
    4. Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan
    • Correspondence to: Hsiao-Lan Sharon Wang, Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei 10016, Taiwan. E-mail: hsiaolanw@gmail.com or Wen-Yih Isaac Tseng, Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan 10016, E-mail: wytseng@ntu.edu.tw or Hai-Gwo Hwu, Graduate Institute of Brain and Mind Science and Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Department of Psychology, College of Science Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan 10016, E-mail: haigohwu@ntu.edu.tw

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Abstract

Schizophrenia has been associated with abnormal task-related brain activation in sensory and motor regions as well as social cognition network. Recently, two studies investigated temporal correlation between resting-state functional magnetic resonance imaging (R-fMRI) low-frequency oscillations (LFOs) in schizophrenia but reported mixed results. This may be due to the different frequency bands used in these studies. Here we utilized R-fMRI to measure the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) in three different frequency bands (slow-5: 0.01–0.027 Hz; slow-4: 0.027–0.08 Hz; and typical band: 0.01–0.08 Hz) in 69 patients with schizophrenia and 62 healthy controls. We showed that there were significant differences in ALFF/fALFF between the two bands (slow-5 and slow-4) in regions including basal ganglia, midbrain, and ventromedial prefrontal cortex. Importantly, we also identified significant interaction between frequency bands and groups in inferior occipital gyrus, precunus, and thalamus. The results suggest that the abnormalities of LFOs in schizophrenia is dependent on the frequency band and suggest that future studies should take the different frequency bands into account when measure intrinsic brain activity. Hum Brain Mapp 35:627–637, 2014. © 2012 Wiley Periodicals, Inc.

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