Sofie M. Adriaanse and Ernesto J. Sanz-Arigita contributed equally to this work.
Amyloid and its association with default network integrity in Alzheimer's disease
Article first published online: 14 DEC 2012
Copyright © 2012 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 35, Issue 3, pages 779–791, March 2014
How to Cite
Adriaanse, S. M., Sanz-Arigita, E. J., Binnewijzend, M. A.A., Ossenkoppele, R., Tolboom, N., van Assema, D. M.E., Wink, A. M., Boellaard, R., Yaqub, M., Windhorst, A. D., van der Flier, W. M., Scheltens, P., Lammertsma, A. A., Rombouts, S. A.R.B., Barkhof, F. and van Berckel, B. N.M. (2014), Amyloid and its association with default network integrity in Alzheimer's disease. Hum. Brain Mapp., 35: 779–791. doi: 10.1002/hbm.22213
- Issue published online: 7 FEB 2014
- Article first published online: 14 DEC 2012
- Manuscript Accepted: 25 SEP 2012
- Manuscript Revised: 24 SEP 2012
- Manuscript Received: 24 MAY 2012
- Internationale Stichting Alzheimer Onderzoek (ISAO). Grant Number: 11539
- Hersenstichting Nederland. Grant Number: KS2011(1)-24
- Alzheimer disease;
- mild cognitive impairment;
- positron emission tomography;
- magnetic resonance imaging;
- default mode network;
- resting-state fMRI
The purpose of this study was to investigate the association between functional connectivity and β-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN. Hum Brain Mapp 35:779–791, 2014. © 2012 Wiley Periodicals, Inc.