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Amyloid and its association with default network integrity in Alzheimer's disease

Authors

  • Sofie M. Adriaanse,

    Corresponding author
    1. Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    • Department of Nuclear Medicine and PET Research, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. E-mail: s.adriaanse@vumc.nl

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    • Sofie M. Adriaanse and Ernesto J. Sanz-Arigita contributed equally to this work.

  • Ernesto J. Sanz-Arigita,

    1. Department of Radiology, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    2. Department of Neuroimage, CITA-Alzheimer Foundation, San Sebastian, Spain
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    • Sofie M. Adriaanse and Ernesto J. Sanz-Arigita contributed equally to this work.

  • Maja A.A. Binnewijzend,

    1. Department of Radiology, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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  • Rik Ossenkoppele,

    1. Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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  • Nelleke Tolboom,

    1. Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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  • Daniëlle M.E. van Assema,

    1. Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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  • Alle Meije Wink,

    1. Department of Radiology, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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  • Ronald Boellaard,

    1. Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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  • Maqsood Yaqub,

    1. Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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  • Albert D. Windhorst,

    1. Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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  • Wiesje M. van der Flier,

    1. Department of Neurology, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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  • Philip Scheltens,

    1. Department of Neurology, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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  • Adriaan A. Lammertsma,

    1. Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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  • Serge A.R.B. Rombouts,

    1. Institute of Psychology, Leiden University, Leiden, The Netherlands
    2. Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    3. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
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  • Frederik Barkhof,

    1. Department of Radiology, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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  • Bart N.M. van Berckel

    1. Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
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Abstract

The purpose of this study was to investigate the association between functional connectivity and β-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN. Hum Brain Mapp 35:779–791, 2014. © 2012 Wiley Periodicals, Inc.

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