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Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis

Authors

  • Laurent Younes,

    1. Center for Imaging Science, Institute for Computational Medicine and Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, Maryland
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  • J. Tilak Ratnanather,

    1. Center for Imaging Science, Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, WSE, Baltimore, Maryland
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  • Timothy Brown,

    1. Center for Imaging Science, Johns Hopkins University, WSE, Baltimore, Maryland
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  • Elizabeth Aylward,

    1. University of Washington, Department of Radiology, Seattle Children's Research Institute, Seattle, Washington
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  • Peg Nopoulos,

    1. Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, Iowa
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  • Hans Johnson,

    1. Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, Iowa
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  • Vincent A. Magnotta,

    1. Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, Iowa
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  • Jane S. Paulsen,

    Corresponding author
    1. Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, Iowa
    • Department of Psychiatry, The University of Iowa Carver College of Medicine, 1-305 Medical Education Building, Iowa City, IA 52242-1000. E-mail: predict-publications@uiowa.edu

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  • Russell L. Margolis,

    1. Departments of Psychiatry and Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • Roger L. Albin,

    1. Department of Neurology, University of Michigan, and VAAAHS Geriatrics Research, Education, and Clinical Center, Ann Arbor, Michigan
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  • Michael I. Miller,

    1. Center for Imaging Science, Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, WSE, Baltimore, Maryland
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  • Christopher A. Ross,

    1. Division of Neurobiology, Departments of Psychiatry, Neurology, Neuroscience and Pharmacology, and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • PREDICT-HD Investigators and Coordinators of the Huntington Study Group


Abstract

Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through “Large Deformation Diffeomorphic Metric Mapping” of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention. Hum Brain Mapp 35:792–809, 2014. © 2012 Wiley Periodicals, Inc.

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